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flavin mononucleotide

Candidate: toolkit item4 source documents7 linked claims
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Aliases

FMN

Evidence Snippets

Flavin mononucleotide (FMN) is a highly efficient photosensitizer
Evidence 1Source 1DOIPubMedprovenance
The extended time scale and wavenumber range allowed us to monitor the complete excited-state dynamics of the biological chromophore flavin mononucleotide (FMN), both free in solution and embedded in two variants of the bacterial light-oxygen-voltage (LOV) photoreceptor EL222.
Evidence 2Source 2DOIPubMedprovenance
a flavin mononucleotide (FMN) cofactor
Evidence 3Source 3DOIPubMedprovenance
the flavin mononucleotide (FMN) cofactor
Evidence 4Source 4DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1application proposalsupports2024Source 1DOIPubMed

AsLOV2 can be used as a vehicle for FMN photosensitizer release triggered by light irradiation.

Quoted textsource-backed
to utilize AsLOV2, due to its inherent binding propensity to FMN, as a PS vehicle, which is released at a target by light irradiation
Claim 2agreement with prior worksupports2023Source 2DOIPubMed

Observed lifetimes and intermediate states including singlet, triplet, and adduct agree with previous time-resolved infrared spectroscopy experiments.

Quoted textsource-backed
The observed lifetimes and intermediate states (singlet, triplet, and adduct) are in agreement with previous time-resolved infrared spectroscopy experiments.
Claim 3method applicationsupports2023Source 2DOIPubMed

The extended time scale and wavenumber range allowed monitoring of the complete excited-state dynamics of FMN free in solution and FMN embedded in two EL222 variants.

Quoted textsource-backed
The extended time scale and wavenumber range allowed us to monitor the complete excited-state dynamics of the biological chromophore flavin mononucleotide (FMN), both free in solution and embedded in two variants of the bacterial light-oxygen-voltage (LOV) photoreceptor EL222.
Claim 4assignmentsupports2011Source 3DOIPubMed

A weak long-lived emission component from 600 to 650 nm in LOV2 was assigned to phosphorescence from the reactive FMN triplet state.

Quoted textsource-backed
A weak long-lived component with emission intensity from 600 to 650 nm was assigned to phosphorescence from the reactive FMN triplet state.
Claim 5measurementsupports2011Source 3DOIPubMed

FMN in aqueous solution showed pH-dependent fluorescence lifetimes of 2.7 ns at pH 2 and 3.9-4.1 ns at pH 3-8.

Quoted textsource-backed
FMN dissolved in aqueous solution showed pH-dependent fluorescence lifetimes of 2.7 ns at pH 2 and 3.9-4.1 ns at pH 3-8.
Claim 6mechanismsupports2011Source 3DOIPubMed

Phototropin light-dependent action is based on reversible formation of a covalent bond between an FMN cofactor and a conserved cysteine in LOV domains.

Quoted textsource-backed
The phototropins are blue-light receptors that base their light-dependent action on the reversible formation of a covalent bond between a flavin mononucleotide (FMN) cofactor and a conserved cysteine in light, oxygen or voltage (LOV) domains.
Claim 7method applicationsupports2010Source 4DOIPubMed

Cryogenic-temperature ENDOR spectroscopy can be applied to LOV domains to gain information on the direct vicinity of the FMN cofactor by analyzing the temperature dependence of methyl-group rotation attached to C(8) of the FMN isoalloxazine ring.

Quoted textsource-backed
we describe how cryogenic-temperature ENDOR spectroscopy can be applied to various LOV domains ... to gain information on the direct vicinity of the flavin mononucleotide (FMN) cofactor by analyzing the temperature dependence of methyl-group rotation attached to C(8) of the FMN's isoalloxazine ring