First-pass extracted concept

Fragile X messenger ribonucleoprotein

Candidate: toolkit item1 source documents4 linked claims

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Aliases

FMRP

Evidence Snippets

Fragile X messenger ribonucleoprotein (FMRP) is an RNA-binding protein implicated in autism that suppresses translation and forms granules.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2023DOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional importancesupports2023Source 1DOI PubMed

Stable FMRP granule association is essential for function.

Quoted textsource-backed

underscoring the essential nature of FMRP granule association for function

Claim 2overall conclusionsupports2023Source 1DOI PubMed

FMRP phospho-state alters granule structure, transport, and translation to regulate local protein synthesis spatiotemporally.

Quoted textsource-backed

Thus, the phospho-state of FMRP altered the structure of individual granules with changes in transport and translation to achieve spatiotemporal regulation of local protein synthesis.

Claim 3phosphorylation effectsupports2023Source 1DOI PubMed

Phosphorylation at FMRP serine 499 altered granule puncta size, intensity, contrast, and transport.

Quoted textsource-backed

phosphorylation on serine 499 (S499) led to differences in puncta size, intensity, contrast, and transport as shown by phospho-deficient (S499A) and phospho-mimic (S499D) mutant FMRP granules

Claim 4translation regulationsupports2023Source 1DOI PubMed

Phosphorylated FMRP can attenuate translation.

Quoted textsource-backed

suggesting that phosphorylated FMRP can attenuate translation