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First-pass extracted concept

GSK-3beta

Candidate: toolkit item1 source documents3 linked claims
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Aliases

glycogen synthase kinase 3beta, GSK-3β

Evidence Snippets

subsequent GSK-3beta (glycogen synthase kinase 3beta)-mediated phosphorylation of Ser553
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1functional rolesupports2010Source 1DOIPubMed

DYRK1A is a clock component that cooperates with GSK-3beta and governs Ser557 phosphorylation-triggered degradation of CRY2.

Quoted textsource-backed
DYRK1A is a novel clock component cooperating with GSK-3beta and governs the Ser557 phosphorylation-triggered degradation of CRY2.
Claim 2mechanismsupports2010Source 1DOIPubMed

DYRK1A phosphorylates CRY2 at Ser557 as a priming event for subsequent GSK-3beta-mediated phosphorylation of Ser553.

Quoted textsource-backed
Ser557 in the C-terminal tail of CRY2 is phosphorylated by DYRK1A as a priming kinase for subsequent GSK-3beta (glycogen synthase kinase 3beta)-mediated phosphorylation of Ser553
Claim 3mechanismsupports2010Source 1DOIPubMed

The DYRK1A- and GSK-3beta-directed phosphorylation events lead to proteasomal degradation of CRY2.

Quoted textsource-backed
which leads to proteasomal degradation of CRY2