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First-pass extracted concept

independent denaturable structural element

Candidate: toolkit item1 source documents3 linked claims
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Aliases

an additional element with a denaturable structure, independent element

Evidence Snippets

an additional element with a denaturable structure
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Source 1primary paper2017Frontiers in Molecular NeuroscienceDOIPubMed
1 evidence snippet3 linked claimsClaim 1Claim 2Claim 3

Linked Claims

Claim 1binding affinity effectsupports2017Source 1DOIPubMed

Denaturation causes an approximately 3-fold drop in overall binding affinity of the NOS1AP C-terminal region for nNOS.

Quoted textsource-backed
Denaturation does not affect the functions of the individual motifs and results in a relatively mild drop, ∼3-fold, of overall binding affinity of the C-terminal region of NOS1AP for nNOS
Claim 2competition effectsupports2017Source 1DOIPubMed

Denaturation selectively prevents the concerted action of the motifs that occludes the PDZ ligand-binding pocket and reduces competition between NOS1AP and an alternate PDZ ligand by 30-fold.

Quoted textsource-backed
denaturation selectively prevents the concerted action of the two motifs that normally results in efficient occlusion of the PDZ ligand-binding pocket, and results in 30-fold reduction of competition between NOS1AP and an alternate PDZ ligand
Claim 3structural contributorsupports2017Source 1DOIPubMed

An additional denaturable structural element contributes to interaction of NOS1AP with nNOS.

Quoted textsource-backed
we identify an additional element with a denaturable structure that contributes to interaction of NOS1AP with nNOS