the inositol 1,4,5-trisphosphate receptor (InsP(3)R) Ca(2+) release channel
First-pass extracted concept
InsP(3)R
Candidate: toolkit item1 source documents6 linked claims
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Aliases
inositol 1,4,5-trisphosphate receptor, InsP3 receptor Ca2+ release channel
Evidence Snippets
Supporting Sources
Linked Claims
CIB1 is a ubiquitously expressed ligand of the InsP3 receptor.
Quoted textsource-backed
We have discovered the Ca(2+)-binding protein CIB1 (calmyrin) as a ubiquitously expressed ligand of the InsP(3)R.
CIB1 binds all mammalian InsP3 receptor isoforms in a Ca2+-sensitive manner dependent on its two functional EF-hands.
Quoted textsource-backed
CIB1 binds to all mammalian InsP(3)R isoforms in a Ca(2+)-sensitive manner dependent on its two functional EF-hands
CIB1 activates InsP3 receptor channel gating in the absence of InsP3.
Quoted textsource-backed
and activates InsP(3)R channel gating in the absence of InsP(3)
CIB1 is a ubiquitously expressed activating and inhibiting protein ligand of the InsP3 receptor.
Quoted textsource-backed
These results establish CIB1 as a ubiquitously expressed activating and inhibiting protein ligand of the InsP(3)R.
Overexpression of CIB1 attenuates InsP3 receptor-dependent Ca2+ signaling.
Quoted textsource-backed
In contrast, overexpression of CIB1 or CaBP1 attenuated InsP(3)R-dependent Ca(2+) signaling
In vitro pre-exposure to CIB1 reduces the number of InsP3 receptor channels available for subsequent stimulation by InsP3.
Quoted textsource-backed
in vitro pre-exposure to CIB1 reduced the number of channels available for subsequent stimulation by InsP(3)