First-pass extracted concept

insulin-like growth factor 1

Candidate: toolkit item1 source documents5 linked claims

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Aliases

IGF-1

Evidence Snippets

cerebellar levels of insulin-like growth factor 1 (IGF-1) are high during light cycles and low during dark cycles

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2012Proceedings of the National Academy of SciencesDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1activity effectsupports2012Source 1DOI PubMed

Exogenous IGF-1 accelerates migration of isolated granule cells through activation of IGF-1 receptors in vitro.

Quoted textsource-backed

in vitro studies indicate that exogenous IGF-1 accelerates the migration of isolated granule cells through the activation of IGF-1 receptors

Claim 2causal relationshipsupports2012Source 1DOI PubMed

Changes in light-dark cycles result in corresponding changes in both granule cell migration speed and cerebellar IGF-1 levels.

Quoted textsource-backed

changes in light-dark cycles result in corresponding changes in the fluctuations of both speed of granule cell migration and cerebellar IGF-1 levels

Claim 3environmental regulationsupports2012Source 1DOI PubMed

In early postnatal mouse cerebella, granule cell migration accelerates during light cycles and decelerates during dark cycles.

Quoted textsource-backed

in early postnatal mouse cerebella, granule cell migration accelerates during light cycles and decelerates during dark cycles

Claim 4mechanistic modelsupports2012Source 1DOI PubMed

During early postnatal development, light stimuli control granule cell migration by altering IGF-1 receptor activity through modification of cerebellar IGF-1 levels.

Quoted textsource-backed

These results suggest that during early postnatal development light stimuli control granule cell migration by altering the activity of IGF-1 receptors through modification of cerebellar IGF-1 levels

Claim 5molecular level changesupports2012Source 1DOI PubMed

Cerebellar IGF-1 levels are high during light cycles and low during dark cycles.

Quoted textsource-backed

cerebellar levels of insulin-like growth factor 1 (IGF-1) are high during light cycles and low during dark cycles