First-pass extracted concept

integrin alphaIIbbeta3

Candidate: toolkit item2 source documents7 linked claims

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Aliases

alphaIIbbeta3, alphaIIbbeta3 integrin

Evidence Snippets

Platelet aggregation requires activation of the alphaIIbbeta3 integrin.

Evidence 1Source 1DOI PubMedprovenance

the alphaIIbbeta3 integrin on platelets

Evidence 2Source 2DOI PubMedprovenance

Supporting Sources

Source 1primary paper2008Thrombosis and HaemostasisDOI PubMed

1 evidence snippet 2 linked claims Claim 1 Claim 2

Source 2primary paper2006The Journal of Cell BiologyDOI PubMed

1 evidence snippet 5 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1binding interactionsupports2008Source 1DOI PubMed

CIB1 binds to the cytoplasmic tail of the integrin alphaIIb subunit.

Quoted textsource-backed

CIB1 binds to the cytoplasmic tail of the integrin alphaIIb subunit.

Claim 2regulatory effectsupports2008Source 1DOI PubMed

Previous over-expression and knockdown studies in murine megakaryocytes demonstrated that CIB1 inhibits integrin alphaIIbbeta3 activation.

Quoted textsource-backed

Previous over-expression and knockdown studies in murine megakaryocytes demonstrated that CIB1 inhibits integrin alphaIIbbeta3 activation.

Claim 3functional rolesupports2006Source 2DOI PubMed

CIB1 is an endogenous inhibitor of agonist-induced integrin alphaIIbbeta3 activation.

Quoted textsource-backed

We report that calcium and integrin binding protein 1 (CIB1), which interacts directly with the alphaIIb tail, is an endogenous inhibitor of alphaIIbbeta3 activation

Claim 4mechanistic modelsupports2006Source 2DOI PubMed

CIB1 appears to inhibit integrin activation by competing with talin for binding to alphaIIbbeta3.

Quoted textsource-backed

CIB1 appears to inhibit integrin activation by competing with talin for binding to alphaIIbbeta3

Claim 5molecular interactionsupports2006Source 2DOI PubMed

CIB1 interacts directly with the alphaIIb tail.

Quoted textsource-backed

CIB1), which interacts directly with the alphaIIb tail

Claim 6perturbation effectsupports2006Source 2DOI PubMed

Overexpression of CIB1 in megakaryocytes blocks agonist-induced alphaIIbbeta3 activation.

Quoted textsource-backed

overexpression of CIB1 in megakaryocytes blocks agonist-induced alphaIIbbeta3 activation

Claim 7perturbation effectsupports2006Source 2DOI PubMed

Reduction of endogenous CIB1 via RNA interference enhances alphaIIbbeta3 activation.

Quoted textsource-backed

reduction of endogenous CIB1 via RNA interference enhances activation