First-pass extracted concept

integrin αIIbβ3

Candidate: toolkit item1 source documents4 linked claims

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Aliases

fibrinogen receptor

Evidence Snippets

On circulating platelets, integrin αIIbβ3, the fibrinogen receptor, is in a low affinity state unable to bind soluble ligands.

Evidence 1Source 1DOIprovenance

Supporting Sources

Source 1primary paper2008BloodDOI

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic modelsupports2008Source 1DOI

CIB1 regulates hemostasis by supporting the transition of platelets from filopodial stage to fully spread morphology during outside-in signaling through integrin αIIbβ3.

Quoted textsource-backed

These in vivo and in vitro results clearly show that CIB1 regulates hemostasis by supporting transition of platelets from filopodial stage to fully spread morphology during outside-in signaling through integrin αIIbβ3.

Claim 2molecular interactionsupports2008Source 1DOI

CIB1 specifically interacts with integrin αIIbβ3.

Quoted textsource-backed

Previously, we have identified a calcium- and integrin-binding protein 1 (CIB1) that specifically interacts with integrin αIIbβ3.

Claim 3phenotype effectsupports2008Source 1DOI

Absence of CIB1 affects the ability of platelets to spread on immobilized fibrinogen.

Quoted textsource-backed

The absence of CIB1 also affects the ability of platelets to spread on immobilized Fg.

Claim 4regulatory rolesupports2008Source 1DOI

CIB1 regulates outside-in signaling through integrin αIIbβ3.

Quoted textsource-backed

Using a novel technique to inhibit interaction of CIB1 with integrin in vivo, we have shown that CIB1 regulates outside-in signaling through integrin αIIbβ3.