First-pass extracted concept

LILAC

Candidate: toolkit item1 source documents3 linked claims

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Aliases

improved Lifeact variant, optogenetic Lifeact

Evidence Snippets

LILAC: Enhanced actin imaging with an optogenetic Lifeact. We have designed an improved Lifeact variant that binds to actin under the control of light using the LOV2 protein.

Evidence 1Source 1DOIprovenance

Supporting Sources

Source 1primary paper2022DOI

1 evidence snippet 3 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1design featuresupports2022Source 1DOI

LILAC is an improved Lifeact variant that binds to actin under light control using the LOV2 protein.

Quoted textsource-backed

We have designed an improved Lifeact variant that binds to actin under the control of light using the LOV2 protein.

Claim 2imaging advantagesupports2022Source 1DOI

Light control allows subtraction of pre-illumination signal from unbound label, yielding an enhanced view of F-actin dynamics in cells.

Quoted textsource-backed

Light control enables one to subtract the pre-illumination signal of the unbound label, yielding an enhanced view of F-actin dynamics in cells.

Claim 3reduced perturbationsupports2022Source 1DOI

LILAC eliminates actin network perturbations and cell sickness caused by Lifeact overexpression.

Quoted textsource-backed

Furthermore, the tool eliminates actin network perturbations and cell sickness caused by Lifeact overexpression.