First-pass extracted concept

LovK

Candidate: toolkit item1 source documents4 linked claims

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Aliases

LOV-histidine kinase, LovK

Evidence Snippets

the LOV-histidine kinase, LovK

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2017BiochemistryDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanistic conservationsupports2017Source 1DOI PubMed

Across AsLOV2, YtvA, EL222, and LovK, the overall pathway leading to cysteine adduct formation from the FMN triplet state is highly conserved despite differences in tertiary structure.

Quoted textsource-backed

Despite differences in tertiary structure, the overall pathway leading to cysteine adduct formation from the FMN triplet state is highly conserved, although there are slight variations in rate.

Claim 2post adduct kinetic divergencesupports2017Source 1DOI PubMed

After adduct formation, vibrational spectra and kinetics differ significantly among the full-length LOV photoreceptors and are directly linked to the specific output function of the LOV domain.

Quoted textsource-backed

However, significant differences are observed in the vibrational spectra and kinetics after adduct formation, which are directly linked to the specific output function of the LOV domain.

Claim 3rate variationsupports2017Source 1DOI PubMed

The rate of adduct formation varies by only 3.6-fold among the studied LOV proteins.

Quoted textsource-backed

While the rate of adduct formation varies by only 3.6-fold among the proteins

Claim 4structural change timescalesupports2017Source 1DOI PubMed

Large-scale structural changes in the full-length LOV photoreceptors occur over micro- to submillisecond time scales and vary by orders of magnitude depending on output function.

Quoted textsource-backed

the subsequent large-scale structural changes in the full-length LOV photoreceptors occur over the micro- to submillisecond time scales and vary by orders of magnitude depending on the different output function of each LOV domain.