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First-pass extracted concept

MAP1A light chain-2

Candidate: toolkit item1 source documents6 linked claims
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Aliases

LC2, MAP1A/LC2

Evidence Snippets

LC2, the light chain of the microtubule-associated protein MAP1A
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1binding determinantsupports2007Source 1DOIPubMed

GTP binding and the 18-amino acid C-terminal hypervariable domain of RhoB are critical for binding to MAP1A/LC2.

Quoted textsource-backed
GTP binding and the 18-amino acid C-terminal hypervariable domain of RhoB are critical for its binding to MAP1A/LC2
Claim 2cellular interaction contextsupports2007Source 1DOIPubMed

The RhoB-MAP1A/LC2 interaction occurs in U87 cells.

Quoted textsource-backed
Coimmunoprecipitation and immunofluorescence experiments showed that this interaction occurs in U87 cells
Claim 3functional perturbationsupports2007Source 1DOIPubMed

Down-regulation of MAP1A/LC2 expression decreased EGF receptor expression and modified the signaling response to EGF treatment.

Quoted textsource-backed
Down-regulation of MAP1A/LC2 expression decreased epidermal growth factor (EGF) receptor expression and modified the signaling response to EGF treatment
Claim 4functional rolesupports2007Source 1DOIPubMed

MAP1A/LC2 is critical for RhoB function in EGF-induced EGF receptor regulation.

Quoted textsource-backed
We concluded that MAP1A/LC2 is critical for RhoB function in EGF-induced EGF receptor regulation
Claim 5mechanistic hypothesisneutral2007Source 1DOIPubMed

The RhoB and MAP1A/LC2 interaction may facilitate endocytic vesicle trafficking and regulate trafficking of signaling molecules.

Quoted textsource-backed
we postulate that the RhoB and MAP1A/LC2 interactions facilitate endocytic vesicle trafficking and regulate the trafficking of signaling molecules
Claim 6molecular interactionsupports2007Source 1DOIPubMed

MAP1A light chain-2 is a novel binding partner for RhoB.

Quoted textsource-backed
we identified LC2, the light chain of the microtubule-associated protein MAP1A, as a novel binding partner for RhoB