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metarhodopsin II

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Aliases

M II

Evidence Snippets

The results strongly suggest that the active state is metarhodopsin II (M II).
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1interaction mechanismsupports1982Source 1locatorDOIPubMed

Metarhodopsin II is the major active rhodopsin photoproduct involved in light-induced interaction with the GTP-binding protein.

Quoted textsource-backed
The results strongly suggest that the active state is metarhodopsin II (M II).
Claim 2ligand effectsupports1982Source 1locatorDOIPubMed

Addition of GTP reverses the GTP-binding protein-induced shift toward metarhodopsin II by dissociating the rhodopsin-GTP-binding protein complex.

Quoted textsource-backed
addition of GTP-binding protein to a suspension of extracted membranes bleached at 2 degrees C (pH 8.3) shifts the metarhodopsin I in equilibrium metarhodopsin II equilibrium towards metarhodopsin II. The shift is reversed by GTP, which dissociates the rhodopsin--GTP-binding protein complex.
Claim 3state specific bindingsupports1982Source 1locatorDOIPubMed

Metarhodopsin II induces binding of the GTP-binding protein whereas metarhodopsin I does not, indicating lower affinity of the GTP-binding protein for metarhodopsin I.

Quoted textsource-backed
At low ionic strength, where the GTP-binding protein is soluble in the dark (instead of being associated to the membrane as in the above experiments) M II still induces the binding whereas M I does not, indicating a much lower affinity of the GTP-binding protein for MI.