First-pass extracted concept

myosin IIA

Candidate: toolkit item1 source documents3 linked claims

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Aliases

NMIIA

Evidence Snippets

We show that dactylopodia and filopodia protrusions are balanced by myosin IIA (NMIIA) and actin-related protein 2/3 (Arp2/3) activity.

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2021Proceedings of the National Academy of SciencesDOI PubMed

Linked Claims

Claim 1mechanistic relationshipsupports2021Source 1DOI PubMed

NMIIA inhibits Rac1-dependent activation of Arp2/3 by regulating the maturation state of focal adhesions.

Quoted textsource-backed

We further show that NMIIA inhibits Rac1-dependent activation of Arp2/3 by regulating the maturation state of focal adhesions.

Claim 2perturbation effectsupports2021Source 1DOI PubMed

Endothelial cell-autonomous ablation of NMIIA promotes excessive dactylopodia formation at the expense of filopodia.

Quoted textsource-backed

Endothelial cell-autonomous ablation of NMIIA promotes excessive dactylopodia formation in detriment of filopodia.

Claim 3regulatory relationshipsupports2021Source 1DOI PubMed

Dactylopodia and filopodia protrusions are balanced by myosin IIA and Arp2/3 activity.

Quoted textsource-backed

We show that dactylopodia and filopodia protrusions are balanced by myosin IIA (NMIIA) and actin-related protein 2/3 (Arp2/3) activity.