Here we present a near‐infrared (NIR) light‐controlled nanosystem that allows spatiotemporally controlled regulation of gene expression and thus combinational tumor therapy.
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near-infrared light-controlled nanosystem
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NIR light-controlled nanosystem
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The near-infrared light-controlled nanosystem allows spatiotemporally controlled regulation of gene expression and combinational tumor therapy.
Quoted textsource-backed
Here we present a near‐infrared (NIR) light‐controlled nanosystem that allows spatiotemporally controlled regulation of gene expression and thus combinational tumor therapy.
The nanosystem is built from an enzyme-activatable antisense oligonucleotide combined with an upconversion nanoparticle-based photodynamic system and a mitochondria localization signal.
Quoted textsource-backed
The nanosystem is built by engineering of an enzyme‐activatable antisense oligonucleotide and further combination with an upconversion nanoparticle‐based photodynamic system and a mitochondria localization signal.
The system relies on photodynamic effect-induced translocation of a DNA repair enzyme from nucleus into mitochondria, enabling spatially selective gene regulation via enzymatic reactions.
Quoted textsource-backed
The system relies on photodynamic effect‐induced translocation of a DNA repair enzyme from nucleus into mitochondria, which enables spatially selective gene regulation via enzymatic reactions.
NIR light-induced mitochondrial photodamage and gene regulation enable an enhanced antitumor effect.
Quoted textsource-backed
We demonstrate that the NIR light‐induced mitochondrial photodamage and gene regulation enable enhanced antitumor effect.