NOS1AP C-Terminus; C-terminal region of NOS1AP
First-pass extracted concept
NOS1AP C-terminus
Candidate: toolkit item1 source documents4 linked claims
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Aliases
C-terminal region of NOS1AP
Evidence Snippets
Supporting Sources
Linked Claims
Denaturation causes an approximately 3-fold drop in overall binding affinity of the NOS1AP C-terminal region for nNOS.
Quoted textsource-backed
Denaturation does not affect the functions of the individual motifs and results in a relatively mild drop, ∼3-fold, of overall binding affinity of the C-terminal region of NOS1AP for nNOS
The concerted action of the NOS1AP ExF region and PDZ ligand motif efficiently excludes an alternate ligand from the nNOS PDZ ligand-binding pocket.
Quoted textsource-backed
the concerted action of two previously described motif regions contributing to the interaction of nNOS with NOS1AP, the ExF region and the PDZ ligand motif, efficiently excludes an alternate ligand from the nNOS-PDZ ligand-binding pocket
Denaturation selectively prevents the concerted action of the motifs that occludes the PDZ ligand-binding pocket and reduces competition between NOS1AP and an alternate PDZ ligand by 30-fold.
Quoted textsource-backed
denaturation selectively prevents the concerted action of the two motifs that normally results in efficient occlusion of the PDZ ligand-binding pocket, and results in 30-fold reduction of competition between NOS1AP and an alternate PDZ ligand
An additional denaturable structural element contributes to interaction of NOS1AP with nNOS.
Quoted textsource-backed
we identify an additional element with a denaturable structure that contributes to interaction of NOS1AP with nNOS