the nuclear localization of the Notch intracellular Domain (NICD)
First-pass extracted concept
Notch intracellular domain
Candidate: toolkit item1 source documents5 linked claims
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Aliases
N1ICD, NICD
Evidence Snippets
Supporting Sources
Linked Claims
Discrete changes in nuclear N1ICD abundance are translated into assembly of transcriptional condensates that facilitate gene expression by enriching essential transcriptional machineries at target genomic loci.
Quoted textsource-backed
discrete changes in nuclear N1ICD abundance are translated into the assembly of transcriptional condensates that facilitate gene expression by enriching essential transcriptional machineries at target genomic loci
Formation of N1ICD transcriptional condensates promotes Notch-mediated super enhancer-looping and concomitant activation of MYC protooncogene expression.
Quoted textsource-backed
the formation of such transcriptional condensates acts to promote Notch-mediated super enhancer-looping and concomitant activation of the MYC protooncogene expression
N1ICD can form condensates that positively facilitate Notch target gene expression.
Quoted textsource-backed
we show that the N1ICD can form condensates that positively facilitate Notch target gene expression
N1ICD undergoes Phase Separation Coupled Percolation into transcriptional condensates that recruit, enrich, and encapsulate a broad set of core transcriptional proteins.
Quoted textsource-backed
We determined that N1ICD undergoes Phase Separation Coupled Percolation (PSCP) into transcriptional condensates, which recruit, enrich, and encapsulate a broad set of core transcriptional proteins.
The capacity of N1ICD for condensation is due to its intrinsically disordered transcriptional activation domain.
Quoted textsource-backed
We show that the capacity for condensation is due to the intrinsically disordered transcriptional activation domain of the N1ICD.