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First-pass extracted concept

OmniNeo

Candidate: toolkit itemType: computation method1 source documents4 linked claims
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Extracted Explainers

What the tool is doing

OmniNeo is an automated multi-omics neoantigen discovery framework for identifying and prioritizing candidate neoantigen epitopes. It combines genomic, transcriptomic, and proteomic evidence with filtering and AI-based ranking.

Source 1DOIPubMed

Resources required

The workflow requires WGS/WES, transcriptomic, and proteomics data and is implemented on Nextflow. Its use therefore depends on access to these omics inputs and a compatible workflow execution environment.

Source 1DOIPubMed

What problem it solves

It addresses the limited comprehensiveness of genomics-only neoantigen pipelines by integrating multiple omics layers and additional filtering. It also aims to improve portability and usability through a one-stop workflow.

Source 1DOIPubMed

What it does not solve

The provided abstract does not show that OmniNeo alone guarantees clinical efficacy or broad validation across many tumor types. It also does not provide detailed benchmark metrics in the supplied evidence.

Source 1DOIPubMed

Alternatives

The source context identifies comparable neoantigen workflows such as nextNEOpi and TSNAD v2.0, and related proteogenomic approaches such as NeoDisc. These are presented as nearby methods covering overlapping neoantigen discovery tasks.

Source 1DOIPubMed

Evidence Snippets

we developed OmniNeo, an automated multi-omics-based neoantigen discovery framework
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1application demosupports2025Source 1DOIPubMed

The authors demonstrated practical application procedures of OmniNeo through case study analyses of liver cancer samples for potential tumor immunotherapy.

Quoted textsource-backed
we demonstrated the practical application procedures of this workflow in potential tumor immunotherapy through case study analyses of liver cancer samples
Claim 2capabilitysupports2025Source 1DOIPubMed

OmniNeo integrates WGS/WES, transcriptomic, and proteomics data to identify neoantigenic epitopes from SNVs/Indels, frameshift mutations, gene fusions, and non-coding region variations.

Quoted textsource-backed
OmniNeo integrates whole-genome/exome sequencing (WGS/WES), transcriptomic, and proteomics data to simultaneously identify neoantigenic epitopes derived from SNVs/Indels, frameshift mutations, gene fusions, and non-coding region variations
Claim 3capabilitysupports2025Source 1DOIPubMed

OmniNeo is an automated multi-omics-based neoantigen discovery framework.

Quoted textsource-backed
we developed OmniNeo, an automated multi-omics-based neoantigen discovery framework
Claim 4implementationsupports2025Source 1DOIPubMed

The OmniNeo workflow is built on Nextflow and is presented as a one-stop, scalable, and portable solution for rapid and efficient neoantigen prediction.

Quoted textsource-backed
The workflow is built on nextflow, offering a one-stop, scalable, and portable solution for rapid and efficient neoantigen prediction