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phosphatidylinositol-4-phosphate

Candidate: toolkit item1 source documents5 linked claims
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Aliases

PI4P

Evidence Snippets

Phosphatidylinositol-4-phosphate (PI4P)
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1biological rolesupports2019Source 1DOIPubMed

FAPP1 controls PI4P levels and acts as a gatekeeper of Golgi exit.

Quoted textsource-backed
FAPP1, by controlling PI4P levels, acts as a gatekeeper of Golgi exit
Claim 2functional requirementsupports2019Source 1DOIPubMed

ER–TGN contact sites are necessary but not sufficient for Sac1 phosphatase activity on TGN PI4P because FAPP1 is also required.

Quoted textsource-backed
The ERTGoCS, though necessary, are not sufficient for the phosphatase activity of Sac1 on TGN PI4P, since this needs the phosphatidyl-four-phosphate-adaptor-protein-1 (FAPP1).
Claim 3functional requirementsupports2019Source 1DOIPubMed

ER–TGN contact sites provide a spatial setting suitable for Sac1 to dephosphorylate PI4P at the TGN.

Quoted textsource-backed
the contact sites between the ER and the TGN (ERTGoCS) provide a spatial setting suitable for Sac1 to dephosphorylate PI4P at the TGN
Claim 4mechanistic modelsupports2019Source 1DOIPubMed

FAPP1 acts as a PI4P detector and adaptor that positions Sac1 close to TGN domains with elevated PI4P concentrations, allowing PI4P consumption.

Quoted textsource-backed
We envision that FAPP1, acting as a PI4P detector and adaptor, positions Sac1 close to TGN domains with elevated PI4P concentrations allowing PI4P consumption.
Claim 5perturbation effectsupports2019Source 1DOIPubMed

FAPP1 depletion increases TGN PI4P and leads to increased secretion of selected cargoes such as ApoB100.

Quoted textsource-backed
FAPP1 depletion induces an increase in TGN PI4P that leads to increased secretion of selected cargoes (e.g., ApoB100)