First-pass extracted concept

phototropin 2

Candidate: toolkit item1 source documents4 linked claims

Jump to evidence Jump to sources Jump to claims

Live refresh every 5sNext refresh in 5s

Aliases

PHOT2

Evidence Snippets

The blue-light photoreceptors, cryptochrome (CRY) 2 and phototropin (PHOT) 2, are required for the stability of the R protein HRT

Evidence 1Source 1DOI PubMedprovenance

Supporting Sources

Source 1primary paper2010Proceedings of the National Academy of SciencesDOI PubMed

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1functional requirementsupports2010Source 1DOI PubMed

CRY2 and PHOT2 are required for HRT stability and thereby resistance to Turnip Crinkle virus.

Quoted textsource-backed

The blue-light photoreceptors, cryptochrome (CRY) 2 and phototropin (PHOT) 2, are required for the stability of the R protein HRT, and thereby resistance to Turnip Crinkle virus (TCV).

Claim 2genetic compensationsupports2010Source 1DOI PubMed

HRT overexpression compensates for absence of PHOT2 but not absence of CRY2.

Quoted textsource-backed

Overexpression of HRT can compensate for the absence of PHOT2 but not CRY2.

Claim 3mechanistic modelsupports2010Source 1DOI PubMed

CRY2 and PHOT2 negatively regulate proteasome-mediated degradation of HRT, likely via COP1, and blue light relieves this repression resulting in HRT degradation.

Quoted textsource-backed

We propose that CRY2/PHOT2 negatively regulate the proteasome-mediated degradation of HRT, likely via COP1, and blue-light relieves this repression resulting in HRT degradation.

Claim 4physical interactionsupports2010Source 1DOI PubMed

HRT does not directly associate with CRY2 or PHOT2 but does bind COP1.

Quoted textsource-backed

HRT does not directly associate with either CRY2 or PHOT2 but does bind the CRY2-/PHOT2-interacting E3 ubiquitin ligase, COP1.