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First-pass extracted concept

resting-state fMRI

Candidate: toolkit itemType: assay method1 source documents3 linked claims
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Aliases

rs-fMRI

Extracted Explainers

What the tool is doing

Resting-state fMRI is used here to measure large-scale functional connectivity across the mouse brain after LC chemogenetic activation.

Source 1DOIPubMed

Resources required

The abstract supports that this approach requires a mouse model and resting-state fMRI measurements combined with LC chemogenetic stimulation.

Source 1DOIPubMed

What problem it solves

It enables whole-brain assessment of how LC activation reconfigures functional networks.

Source 1DOIPubMed

Alternatives

The abstract contrasts this causal mouse perturbation approach with prior human studies that had suggested similar connectivity shifts.

Source 1DOIPubMed

Evidence Snippets

combining chemogenetic activation of the LC with resting-state fMRI
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1correlationsupports2019Source 1DOIPubMed

Functional connectivity changes correlate with transcript levels of alpha-1 and beta-1 adrenergic receptors across the brain.

Quoted textsource-backed
Functional connectivity changes strongly correlate with transcript levels of alpha-1 and beta-1 adrenergic receptors across the brain
Claim 2correlationsupports2019Source 1DOIPubMed

Functional network connectivity correlates with norepinephrine turnover within select brain regions.

Quoted textsource-backed
functional network connectivity correlates with NE turnover within select brain regions
Claim 3method namingsupports2019Source 1DOIPubMed

The paper terms the combination of chemogenetic LC activation and resting-state fMRI "chemo-connectomics."

Quoted textsource-backed
combining chemogenetic activation of the LC with resting-state fMRI, an approach we term "chemo-connectomics."