First-pass extracted concept

SclB

Candidate: toolkit item1 source documents6 linked claims
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Aliases

sclB

Evidence Snippets

the zinc cluster transcription factor SclB
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1antagonistic regulationsupports2018Source 1DOIPubMed

SclB function is antagonistic to VosA and induces expression of flbC, flbD, and brlA.

Quoted textsource-backed
SclB function is antagonistic to VosA, because it induces the expression of early activator genes of asexual differentiation as flbC and flbD as well as brlA.
Claim 2functional linksupports2018Source 1DOIPubMed

SclB links asexual spore formation to synthesis of emericellamides, austinol, and dehydroaustinol and activates the oxidative stress response.

Quoted textsource-backed
SclB links asexual spore formation to the synthesis of secondary metabolites including emericellamides, austinol as well as dehydroaustinol and activates the oxidative stress response of the fungus.
Claim 3negative regulationsupports2018Source 1DOIPubMed

VosA represses a genetic network controlled by sclB.

Quoted textsource-backed
VosA represses a novel genetic network controlled by the sclB gene.
Claim 4positive regulationsupports2018Source 1DOIPubMed

The SclB-controlled network promotes asexual development and spore viability and is independent of fungal light control.

Quoted textsource-backed
The SclB controlled network promotes asexual development and spore viability, but is independent of the fungal light control.
Claim 5promoter regulationsupports2018Source 1DOIPubMed

The VosA-SclB regulatory system includes VosA control of the sclB promoter.

Quoted textsource-backed
The fungal VosA-SclB regulatory system of transcription includes a VosA control of the sclB promoter
Claim 6protein interactionsupports2018Source 1DOIPubMed

SclB interacts with the RcoA transcriptional repressor subunit, suggesting additional inhibitory functions on transcription.

Quoted textsource-backed
SclB interactions with the RcoA transcriptional repressor subunit suggest additional inhibitory functions on transcription.