Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology
First-pass extracted concept
Smad transcription factors
Candidate: toolkit item1 source documents5 linked claims
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Aliases
SMAD, Smad factors
Evidence Snippets
Supporting Sources
Linked Claims
Smad transcription factors are described as core components of the TGFbeta signaling pathway in metazoan biology.
Quoted textsource-backed
Smad transcription factors lie at the core of one of the most versatile cytokine signaling pathways in metazoan biology-the transforming growth factor-beta (TGFbeta) pathway.
The review states that emerging features of Smad-dependent transcription include self-enabled gene response cascades, graded Smad response mechanisms, and Smad-dependent synexpression groups.
Quoted textsource-backed
We are beginning to uncover self-enabled gene response cascades, graded Smad response mechanisms, and Smad-dependent synexpression groups.
Understanding TGFbeta signaling through the Smad pathway is presented as providing general principles for how animal cells translate complex inputs into concrete behavior.
Quoted textsource-backed
Our growing understanding of TGFbeta signaling through the Smad pathway provides general principles for how animal cells translate complex inputs into concrete behavior.
The review summarizes recent progress on Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes.
Quoted textsource-backed
Recent progress has shed light into the processes of Smad activation and deactivation, nucleocytoplasmic dynamics, and assembly of transcriptional complexes.
A diverse set of regulatory devices is described as controlling each step of the Smad pathway.
Quoted textsource-backed
A rich repertoire of regulatory devices exerts control over each step of the Smad pathway.