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small and highly selective mitochondrial-targeted K+ channel

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a small and highly selective K+ channel, which is in mammalian cells targeted into the inner membrane of mitochondria
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1apoptosis effectsupports2020Source 1DOIPubMed

Elevated mitochondrial K+ conductance has no impact on apoptosis.

Quoted textsource-backed
Elevated K+ conductance also results in a decrease in the Ca2+ concentration in the mitochondria but has no impact on apoptosis.
Claim 2expression inductionsupports2020Source 1DOIPubMed

Blue light exposure at very low intensity enables detection of the GFP-tagged channel in mitochondria within less than 1 hour after stimulation.

Quoted textsource-backed
After exposing cells to very low intensities (=0.16 mW/mm<sup>2</sup>) of blue light, the channel protein is detectable as an accumulation of its green fluorescent protein (GFP) tag in the mitochondria less than 1 h after stimulation.
Claim 3physiological effectsupports2020Source 1DOIPubMed

Elevated mitochondrial K+ conductance decreases mitochondrial Ca2+ concentration.

Quoted textsource-backed
Elevated K+ conductance also results in a decrease in the Ca2+ concentration in the mitochondria
Claim 4physiological effectsupports2020Source 1DOIPubMed

Presence of the active mitochondrial K+ channel causes substantial mitochondrial depolarization compatible with the effect of an uncoupler.

Quoted textsource-backed
the presence of an active K+ channel causes a substantial depolarization compatible with the effect of an uncoupler
Claim 5tool developmentsupports2020Source 1DOIPubMed

The authors developed an optogenetic platform that uses the light-sensitive interaction between cryptochrome 2 and CIB1 to trigger transcription of a mitochondrial-targeted K+ channel in mammalian cells.

Quoted textsource-backed
we developed an optogenetic platform for a light-triggered modulation of K+ conductance in mitochondria. By using the light-sensitive interaction between cryptochrome 2 and the regulatory protein CIB1, we can trigger the transcription of a small and highly selective K+ channel, which is in mammalian cells targeted into the inner membrane of mitochondria