Here, we used an optogenetic platform to assess whether recruitment of full-length talin to the plasma membrane was sufficient to induce integrin activation.
First-pass extracted concept
talin
Candidate: toolkit item1 source documents5 linked claims
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Aliases
full-length talin
Evidence Snippets
Supporting Sources
Linked Claims
Blue-light-induced membrane recruitment of talin increases migration of endothelial cells.
Quoted textsource-backed
This resulted in β3 integrin activation in both cell types, as well as increasing migration of the endothelial cells.
Blue-light-induced recruitment of CRY2-talin to the plasma membrane activates β3 integrins in Chinese hamster ovary cells and endothelial cells expressing αIIbβ3 or αVβ3.
Quoted textsource-backed
Thus, exposure of the cells to blue light caused a rapid and reversible recruitment of Arabidopsis cryptochrome 2-talin to the ... plasma membrane. This resulted in β3 integrin activation in both cell types
Plasma membrane recruitment of talin has a role in β3 integrin activation.
Quoted textsource-backed
Altogether, these results define a role for the plasma membrane recruitment of talin in β3 integrin activation
Talin mutations that interfere with direct Rap1 binding abrogate β3 integrin activation.
Quoted textsource-backed
Moreover, talin mutations that interfered with its direct binding to Rap1 abrogated β3 integrin activation.
Membrane recruitment of talin alone is not sufficient for β3 integrin activation because membrane-associated Rap1-GTP is also required.
Quoted textsource-backed
However, membrane recruitment of talin was not sufficient for integrin activation, as membrane-associated Ras-related protein 1 (Rap1)-GTP was also required.