First-pass extracted concept

TRAIL

Candidate: toolkit item1 source documents4 linked claims

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Aliases

cell death-inducing ligand, TRAIL

Evidence Snippets

the cell death-inducing ligand, TRAIL

Evidence 1Source 1DOIprovenance

Supporting Sources

Source 1primary paper2018Cancer ResearchDOI

1 evidence snippet 4 linked claims Claim 1 Claim 2 Claim 3

Linked Claims

Claim 1mechanism of actionsupports2018Source 1DOI

Both CIB1 depletion plus docetaxel and CIB1 depletion plus TRAIL activate paraptosis in addition to death receptor-mediated apoptosis.

Quoted textsource-backed

In addition to death receptor-mediated apoptosis, both combination treatments activated a non-apoptotic mechanism, called paraptosis.

Claim 2resistance overcomingsupports2018Source 1DOI

CIB1 depletion combined with docetaxel or TRAIL induces nearly complete death of docetaxel-resistant MDA-MB-436 cells via apoptosis and paraptosis.

Quoted textsource-backed

Interestingly, these combination treatments also induced nearly complete death of docetaxel-resistant MDA-MB-436 cells, again via apoptosis and paraptosis.

Claim 3selectivitysupports2018Source 1DOI

Neither CIB1 depletion plus docetaxel nor CIB1 depletion plus TRAIL induces cell death in normal ME16C cells.

Quoted textsource-backed

In contrast, neither combination treatment induced cell death in normal ME16C cells.

Claim 4sensitizationsupports2018Source 1DOI

TRAIL alone has no effect on cell viability, but CIB1 depletion sensitizes tumor cells to TRAIL and produces a synergistic increase in cell death.

Quoted textsource-backed

While TRAIL alone had no effect on cell viability, CIB1 depletion profoundly sensitized tumor cells to TRAIL, resulting in a synergistic increase in cell death.