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First-pass extracted concept

transcranial low-intensity focused ultrasound

Candidate: toolkit item1 source documents4 linked claims
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Aliases

tLIFU

Extracted Explainers

What the tool is doing

tLIFU is used here as a non-invasive neuromodulation approach to stimulate a deep pain-related ROI anatomically consistent with the cingulum bundle. In this case report it was applied to treat central post-stroke pain.

Source 1DOIPubMed

Resources required

The abstract indicates that BOLD-fMRI was used to identify an abnormal ROI before tLIFU treatment. Focused ultrasound neuromodulation equipment and clinical follow-up were also required.

Source 1DOIPubMed

What problem it solves

The report presents tLIFU as a potential option for CPSP when prior interventions, including TMS and analgesic management, had provided unsatisfactory relief.

Source 1DOIPubMed

What it does not solve

The abstract does not establish general efficacy, optimal parameters, or mechanism across patients because it describes a single case.

Source 1DOIPubMed

Alternatives

The source contrasts tLIFU with pharmacological treatment, traditional neuromodulation methods, and specifically notes prior transcranial magnetic stimulation (TMS) as unsatisfactory in this patient.

Source 1DOIPubMed

Evidence Snippets

we used transcranial low-intensity focused ultrasound (tLIFU), an emerging non-invasive neuromodulation approach distinct from pharmacological and traditional neuromodulation methods, to treat CPSP patients
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1durabilitysupports2025Source 1DOIPubMed

The analgesic effects of transcranial low-intensity focused ultrasound were sustained throughout a 5-month follow-up period in this case.

Claim 2imaging guided targetingsupports2025Source 1DOIPubMed

BOLD-fMRI identified an abnormal region of interest responsive to analgesic medication adjustments, and this ROI was used to guide tLIFU targeting.

Claim 3safetysupports2025Source 1DOIPubMed

No adverse events were reported during 5 months of follow-up after transcranial low-intensity focused ultrasound in this case.

Claim 4therapeutic effectsupports2025Source 1DOIPubMed

In this case report, transcranial low-intensity focused ultrasound was associated with remarkable pain reduction after 1 week in a patient with central post-stroke pain.