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USP14

Candidate: toolkit item1 source documents4 linked claims
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Aliases

ubiquitin-specific protease 14

Evidence Snippets

We found that ubiquitin-specific protease 14 (USP14) was significantly increased in lenvatinib-resistant HCC cells and tumors.
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1association with resistancesupports2024Source 1DOIPubMed

USP14 is increased in lenvatinib-resistant hepatocellular carcinoma cells and tumors.

Quoted textsource-backed
We found that ubiquitin-specific protease 14 (USP14) was significantly increased in lenvatinib-resistant HCC cells and tumors.
Claim 2functional role in drug resistancesupports2024Source 1DOIPubMed

Silencing USP14 attenuates lenvatinib resistance in hepatocellular carcinoma in vitro and in vivo.

Quoted textsource-backed
Silencing USP14 significantly attenuated lenvatinib resistance in vitro and in vivo.
Claim 3mechanistic interactionsupports2024Source 1DOIPubMed

USP14 directly interacts with and stabilizes CIB1 by reversing K48-linked proteolytic ubiquitination at K24.

Quoted textsource-backed
USP14 directly interacts with and stabilizes calcium- and integrin-binding protein 1 (CIB1) by reversing K48-linked proteolytic ubiquitination at K24
Claim 4pathway facilitationsupports2024Source 1DOIPubMed

USP14-mediated stabilization of CIB1 facilitates the PAK1-ERK1/2 signaling axis.

Quoted textsource-backed
thus facilitating the P21-activated kinase 1 (PAK1)-ERK1/2 signaling axis