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VAC-beta (annexin-8)

Candidate: toolkit item1 source documents6 linked claims
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Aliases

annexin-8, VAC-beta

Evidence Snippets

A 36 kDa calcium/phospholipid binding protein in human placenta was identified as VAC-beta (annexin-8)
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1abundancesupports1992Source 1DOIPubMed

Annexin-8 is a minor product in human placenta, accounting for less than 1% of extracted annexins.

Quoted textsource-backed
The protein is a minor product in placenta, accounting for less than 1% of extracted annexins.
Claim 2chromatography behaviorsupports1992Source 1DOIPubMed

By anion-exchange chromatography on diethylaminoethyl-cellulose, annexin-8 coeluted with annexin-3.

Quoted textsource-backed
By anion-exchange chromatography on diethylaminoethyl-cellulose annexin-8 coeluted with annexin-3.
Claim 3explanation for prior noncharacterizationsupports1992Source 1DOIPubMed

The authors propose that annexin-8 being a minor component in standard annexin preparations and co-eluting with annexin-3 by ion exchange chromatography likely explain why other labs failed to characterize it.

Quoted textsource-backed
The combination of annexin-8 being a minor component in standard annexin preparations and it co-eluting with annexin-3 by ion exchange chromatography are likely to account for the failure of other labs to characterize the product.
Claim 4identificationsupports1992Source 1DOIPubMed

A 36 kDa calcium/phospholipid binding protein in human placenta was identified as VAC-beta (annexin-8).

Quoted textsource-backed
A 36 kDa calcium/phospholipid binding protein in human placenta was identified as VAC-beta (annexin-8) by a combination of immunological and peptide mapping analyses.
Claim 5oligomeric statesupports1992Source 1DOIPubMed

By gel filtration, annexin-8 eluted as a broad peak with approximately half as monomer and half as a heterodimer associated with a 10 kDa subunit.

Quoted textsource-backed
By gel filtration, the protein chromatographed as a broad peak, where half the product eluted as a monomer and half eluted as a heterodimer that was associated with a 10 kDa subunit.
Claim 6yieldsupports1992Source 1DOIPubMed

From 150 g of placenta tissue, only 100 micrograms of annexin-8 was isolated.

Quoted textsource-backed
From 150 g of tissue, only 100 micrograms of the protein was isolated.