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First-pass extracted concept

Vascular endothelial growth factor

Candidate: toolkit item1 source documents8 linked claims
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Aliases

VEGF

Evidence Snippets

Vascular endothelial growth factor (VEGF)
Evidence 1Source 1DOIPubMedprovenance

Supporting Sources

Linked Claims

Claim 1binding interactionsupports1999Source 1DOIPubMed

Various VEGF forms bind to the tyrosine-kinase receptors VEGFR-1 and VEGFR-2, which are expressed almost exclusively in endothelial cells.

Quoted textsource-backed
The various VEGF forms bind to two tyrosine-kinase receptors, VEGFR-1 (flt-1) and VEGFR-2 (KDR/flk-1), which are expressed almost exclusively in endothelial cells.
Claim 2cellular effectsupports1999Source 1DOIPubMed

VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis.

Quoted textsource-backed
VEGF induces endothelial cell proliferation, promotes cell migration, and inhibits apoptosis.
Claim 3disease associationsupports1999Source 1DOIPubMed

Deregulated VEGF expression contributes to solid tumor development by promoting tumor angiogenesis and to additional diseases characterized by abnormal angiogenesis.

Quoted textsource-backed
Deregulated VEGF expression contributes to the development of solid tumors by promoting tumor angiogenesis and to the etiology of several additional diseases that are characterized by abnormal angiogenesis.
Claim 4in vivo effectsupports1999Source 1DOIPubMed

In vivo, VEGF induces angiogenesis and permeabilization of blood vessels and plays a central role in the regulation of vasculogenesis.

Quoted textsource-backed
In vivo VEGF induces angiogenesis as well as permeabilization of blood vessels, and plays a central role in the regulation of vasculogenesis.
Claim 5isoform generationsupports1999Source 1DOIPubMed

Five VEGF isoforms are generated by alternative splicing from a single VEGF gene.

Quoted textsource-backed
Five VEGF isoforms are generated as a result of alternative splicing from a single VEGF gene.
Claim 6molecular propertysupports1999Source 1DOIPubMed

VEGF is a highly specific mitogen for vascular endothelial cells.

Quoted textsource-backed
Vascular endothelial growth factor (VEGF) is a highly specific mitogen for vascular endothelial cells.
Claim 7regulationsupports1999Source 1DOIPubMed

VEGF expression is potentiated in response to hypoxia, activated oncogenes, and a variety of cytokines.

Quoted textsource-backed
The expression of VEGF is potentiated in response to hypoxia, by activated oncogenes, and by a variety of cytokines.
Claim 8therapeutic effectsupports1999Source 1DOIPubMed

Inhibition of VEGF signaling abrogates the development of a wide variety of tumors.

Quoted textsource-backed
Consequently, inhibition of VEGF signaling abrogates the development of a wide variety of tumors.