Source 1primary paper2023Nature Communications
Toolkit/anti-CD47 nanobody (CD47nb)
anti-CD47 nanobody (CD47nb)
Also known as: CD47nb
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The anchor paper describes heat-inducible lysis to release an anti-CD47 nanobody cargo.
Usefulness & Problems
Why this is useful
The anti-CD47 nanobody is the therapeutic cargo released by the engineered bacterial system after heat-inducible lysis. In the source summary it functions as the immunotherapy effector.; therapeutic cargo delivery in engineered bacterial tumor immunotherapy
Source:
The anti-CD47 nanobody is the therapeutic cargo released by the engineered bacterial system after heat-inducible lysis. In the source summary it functions as the immunotherapy effector.
Source:
therapeutic cargo delivery in engineered bacterial tumor immunotherapy
Problem solved
It provides a defined antitumor immunotherapy payload within the remotely controlled bacterial platform.; provides an immunotherapy payload released from engineered bacteria
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It provides a defined antitumor immunotherapy payload within the remotely controlled bacterial platform.
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provides an immunotherapy payload released from engineered bacteria
Problem links
provides an immunotherapy payload released from engineered bacteria
LiteratureIt provides a defined antitumor immunotherapy payload within the remotely controlled bacterial platform.
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It provides a defined antitumor immunotherapy payload within the remotely controlled bacterial platform.
Published Workflows
Objective: Engineer a remotely controllable tumor-homing bacterial immunotherapy system that can be manipulated spatiotemporally by alternating magnetic field to release therapeutic cargo in tumors.
Why it works: The source summary describes a design in which Fe3O4@lipid nanocomposites provide magnetic-field-responsive signal decoding and heat-inducible lysis releases the therapeutic nanobody cargo after the bacteria localize to tumors.
magnetic-to-thermal transductionheat-inducible lysisbacterial tumor hominganti-CD47 nanobody releasebacterial engineeringnanocomposite modificationalternating magnetic field manipulation
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Techniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Magnetic
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: payload burdenoperating role: actuator
Its use in this paper depends on the engineered bacterial chassis and the inducible lysis module that releases the cargo.; requires expression or loading in engineered bacteria and inducible release
The provided evidence does not show that CD47nb by itself provides the spatiotemporal control feature; that depends on the broader system.; the payload does not provide direct comparative efficacy versus other cargos
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The system is described in orthotopic colon tumor models.
The described bacterial system uses Fe3O4@lipid nanocomposites and heat-inducible lysis to enable magnetic-field-linked release of an anti-CD47 nanobody cargo.
The paper reports a tumor-homing engineered bacterial system that is manipulated by alternating magnetic field for precision tumor immunotherapy.
Approval Evidence
1 source1 linked approval claimfirst-pass slug anti-cd47-nanobody-cd47nb
The anchor paper describes heat-inducible lysis to release an anti-CD47 nanobody cargo.
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mechanismsupports
The described bacterial system uses Fe3O4@lipid nanocomposites and heat-inducible lysis to enable magnetic-field-linked release of an anti-CD47 nanobody cargo.
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Comparisons
Source-stated alternatives
The summary references interferon-γ expression in related ultrasound-controlled bacterial systems as a contrasted payload strategy.
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The summary references interferon-γ expression in related ultrasound-controlled bacterial systems as a contrasted payload strategy.
Source-backed strengths
paired with inducible release logic in the described system
Source:
paired with inducible release logic in the described system
Compared with ultrasonography
The summary references interferon-γ expression in related ultrasound-controlled bacterial systems as a contrasted payload strategy.
Shared frame: source-stated alternative in extracted literature
Strengths here: paired with inducible release logic in the described system.
Relative tradeoffs: the payload does not provide direct comparative efficacy versus other cargos.
Source:
The summary references interferon-γ expression in related ultrasound-controlled bacterial systems as a contrasted payload strategy.
Ranked Citations
- 1.