Source 1review2019Journal of Pharmacology and Experimental Therapeutics
Toolkit/assays
assays
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Applications of improved technologies including reagents, assays, model systems, and validated probe compounds will likely increase the delivery of testable hypotheses and therapeutics to enable better health outcomes for patients.
Usefulness & Problems
Why this is useful
Assays are described as improved technologies that can help move testable hypotheses and therapeutics forward in addiction and pain research.; testing therapeutic hypotheses; supporting therapeutic discovery and evaluation
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Assays are described as improved technologies that can help move testable hypotheses and therapeutics forward in addiction and pain research.
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testing therapeutic hypotheses
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supporting therapeutic discovery and evaluation
Problem solved
They are positioned as tools to improve therapeutic testing and discovery workflows.; improving delivery of testable hypotheses and therapeutics
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They are positioned as tools to improve therapeutic testing and discovery workflows.
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improving delivery of testable hypotheses and therapeutics
Problem links
improving delivery of testable hypotheses and therapeutics
LiteratureThey are positioned as tools to improve therapeutic testing and discovery workflows.
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They are positioned as tools to improve therapeutic testing and discovery workflows.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Mechanisms
No mechanism tags yet.
Techniques
Functional AssayTarget processes
recombinationImplementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
The abstract does not specify assay platforms or reagents, only that assays are part of a broader improved-technology toolkit.; requires improved assay technologies, but the abstract does not define exact platforms or protocols
The abstract does not claim that assays alone solve target discovery, clinical translation, or safety challenges.; the abstract does not specify particular assay formats, readouts, or performance characteristics
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Improved technologies including reagents, assays, model systems, and validated probe compounds are likely to increase the delivery of testable hypotheses and therapeutics.
Approval Evidence
1 source1 linked approval claimfirst-pass slug assays
Applications of improved technologies including reagents, assays, model systems, and validated probe compounds will likely increase the delivery of testable hypotheses and therapeutics to enable better health outcomes for patients.
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review summarysupports
Improved technologies including reagents, assays, model systems, and validated probe compounds are likely to increase the delivery of testable hypotheses and therapeutics.
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Comparisons
Source-stated alternatives
Nearby tool categories named in the abstract include reagents, model systems, biomarkers, and validated probe compounds.
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Nearby tool categories named in the abstract include reagents, model systems, biomarkers, and validated probe compounds.
Source-backed strengths
presented as part of improved technologies likely to accelerate better health outcomes
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presented as part of improved technologies likely to accelerate better health outcomes
Compared with barcoded Cre recombinase mRNA barcode platform
assays and barcoded Cre recombinase mRNA barcode platform address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Compared with calcium imaging
assays and calcium imaging address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Relative tradeoffs: appears more independently replicated.
Compared with two-photon excitation microscopy
assays and two-photon excitation microscopy address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Strengths here: looks easier to implement in practice.
Ranked Citations
- 1.