Source 1review2019International Journal of Molecular Sciences
Toolkit/Bcl-xL
Bcl-xL
Also known as: Bcl-xL, Bcl-xL
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studies on the pro-survival protein Bcl-xL. The first high-resolution structure of any Bcl-2 family member was of Bcl-xL, which revealed the conserved topology amongst all family members.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level protein part used inside a larger architecture that realizes a mechanism.
Mechanisms
pro-survival:pro-apoptotic protein complex formationsmall-molecule inhibition of pro-survival bcl-2 family proteinsTechniques
Structural CharacterizationTarget processes
No target processes tagged yet.
Input: Chemical
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Structural studies involving Bcl-xL enabled discovery of the first small-molecule pro-survival protein inhibitors and ultimately contributed to a clinically used cancer drug class.
Structural studies involving Bcl-xL were also the basis for the discovery of the first small-molecule pro-survival protein inhibitors, leading ultimately to the development of a new class of drugs now successfully used for cancer treatment in the clinic.
Structures of Bcl-xL complexes with pro-apoptotic ligands demonstrated the general features of pro-survival:pro-apoptotic complexes.
Subsequent structures of Bcl-xL complexes with pro-apoptotic ligands demonstrated the general features of all pro-survival:pro-apoptotic complexes.
Bcl-xL provided the first high-resolution structure of any Bcl-2 family member and revealed conserved topology among family members.
The first high-resolution structure of any Bcl-2 family member was of Bcl-xL, which revealed the conserved topology amongst all family members.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug bcl-xl
Much of our knowledge of the molecular details of these interactions has come from biochemical and structural studies on the pro-survival protein Bcl-xL. The first high-resolution structure of any Bcl-2 family member was of Bcl-xL, which revealed the conserved topology amongst all family members.
Source:
discovery enablersupports
Structural studies involving Bcl-xL enabled discovery of the first small-molecule pro-survival protein inhibitors and ultimately contributed to a clinically used cancer drug class.
Structural studies involving Bcl-xL were also the basis for the discovery of the first small-molecule pro-survival protein inhibitors, leading ultimately to the development of a new class of drugs now successfully used for cancer treatment in the clinic.
Source:
structural rolesupports
Bcl-xL provided the first high-resolution structure of any Bcl-2 family member and revealed conserved topology among family members.
The first high-resolution structure of any Bcl-2 family member was of Bcl-xL, which revealed the conserved topology amongst all family members.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.