Source 1review2007Molecular BioSystems
Toolkit/caged ligands
caged ligands
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Optical control elements can be classified according to their molecular reversibility as non-reversible phototriggers where light breaks a chemical bond (e.g. caged ligands)
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level protein part used inside a larger architecture that realizes a mechanism.
Techniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2review2011Pharmacological Reviews
Ranked Claims
The reviewed remote-control tools differ in effect direction, onset and offset kinetics, spatial resolution, and invasiveness.
None of the reviewed neuronal remote-control tools is perfect, and each has advantages and disadvantages.
The reviewed tools use light, peptides, and small molecules to primarily activate ion channels and GPCRs, thereby activating or inhibiting neuronal firing.
Remote bidirectional manipulation of neuronal electrical and chemical signaling with high spatiotemporal precision is presented as an ideal approach for linking neural activity to behavior.
Optical control elements can be classified by molecular reversibility into non-reversible phototriggers and reversibly photoisomerizing photoswitches.
Synthetic photoswitches alter channel function using three strategies: tethered photoswitchable ligands, untethered freely diffusing photoswitchable ligands, and photoswitchable crosslinkers.
Nanotoggles are tethered photoswitchable ligands that can either activate channels as agonists or inhibit them as blockers or antagonists.
Optical manipulation of channels has provided insights into the mechanism of channel function.
Approval Evidence
2 sources3 linked approval claimsfirst-pass slug caged-ligands
but also describe other novel techniques that use orthogonal receptors, caged ligands, allosteric modulators, and other approaches.
Source:
Optical control elements can be classified according to their molecular reversibility as non-reversible phototriggers where light breaks a chemical bond (e.g. caged ligands)
Source:
comparison summarysupports
The reviewed remote-control tools differ in effect direction, onset and offset kinetics, spatial resolution, and invasiveness.
Source:
limitation summarysupports
None of the reviewed neuronal remote-control tools is perfect, and each has advantages and disadvantages.
Source:
classificationsupports
Optical control elements can be classified by molecular reversibility into non-reversible phototriggers and reversibly photoisomerizing photoswitches.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.
- 2.