Source 1review2017Annual Review of Biochemistry
Toolkit/CarH
CarH
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The prototype of these B12-dependent photoreceptors, the transcriptional repressor CarH, is widespread in bacteria and mediates light-dependent gene regulation in a photoprotective cellular response. CarH activity as a transcription factor relies on the modulation of its oligomeric state by 5'-deoxyadenosylcobalamin and light.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Mechanisms
cofactor-dependent oligomerization state controllight-dependent regulationOligomerizationtranscriptional repressionTechniques
No technique tags yet.
Target processes
transcriptionInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
CarH is a bacterial prototype B12-dependent photoreceptor that mediates light-dependent gene regulation in a photoprotective cellular response.
CarH transcription factor activity depends on modulation of its oligomeric state by 5'-deoxyadenosylcobalamin and light.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug carh
The prototype of these B12-dependent photoreceptors, the transcriptional repressor CarH, is widespread in bacteria and mediates light-dependent gene regulation in a photoprotective cellular response. CarH activity as a transcription factor relies on the modulation of its oligomeric state by 5'-deoxyadenosylcobalamin and light.
Source:
function summarysupports
CarH is a bacterial prototype B12-dependent photoreceptor that mediates light-dependent gene regulation in a photoprotective cellular response.
Source:
mechanism summarysupports
CarH transcription factor activity depends on modulation of its oligomeric state by 5'-deoxyadenosylcobalamin and light.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.