Source 1primary paper2021Nature Chemical Biology
Toolkit/circularly permuted LOV2
circularly permuted LOV2
Also known as: cpLOV2
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Circularly permuted LOV2 (cpLOV2) is a LOV2-derived protein-domain photoswitch described as a modular component for optogenetic engineering. The supplied evidence supports its identity as a light-responsive module but does not provide additional functional or performance detail.
Usefulness & Problems
Why this is useful
cpLOV2 is useful as a modular photoswitch for optogenetic engineering according to the supplied source. The evidence does not specify target processes, operating wavelengths, or application contexts beyond this general role.
Source:
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering
Problem solved
cpLOV2 is presented as addressing the need for a modular light-responsive domain that can be incorporated into optogenetic designs. The supplied evidence does not further define the specific engineering bottleneck or biological control problem solved.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level protein part used inside a larger architecture that realizes a mechanism.
Mechanisms
photoswitchingTechniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Implementation Constraints
The name indicates that cpLOV2 is based on a circularly permuted LOV2 domain, consistent with protein-domain engineering. However, the supplied evidence does not provide construct architecture, chromophore requirements, expression conditions, or delivery guidance.
The evidence is extremely limited and does not report mechanism details beyond photoswitching, dynamic range, kinetics, spectral properties, or biological validation. It also does not describe host systems, target proteins, or experimental assays.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Circularly permuted LOV2 is presented as a modular photoswitch for optogenetic engineering.
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering
Approval Evidence
1 source1 linked approval claimfirst-pass slug circularly-permuted-lov2
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering
Source:
tool functionsupports
Circularly permuted LOV2 is presented as a modular photoswitch for optogenetic engineering.
Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering
Source:
Comparisons
Source-backed strengths
A supported strength is its presentation as a modular photoswitch, which implies intended portability in engineered optogenetic constructs. No quantitative data, benchmark comparisons, or validation results are provided in the supplied evidence.
Ranked Citations
- 1.