Source 1review2021Frontiers in Molecular Biosciences
Toolkit/down-conversion phosphors
down-conversion phosphors
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Down-conversion phosphors are material-based light-delivery harnesses explored for remote optogenetic control of neuronal activity in living animals. They are used in wireless, less invasive optical stimulation strategies to control cellular functions in the brain and other tissues.
Usefulness & Problems
Why this is useful
These phosphor-based approaches are useful because they aim to deliver optogenetic stimulation remotely without relying on fiber optics placed close to the target tissue. The cited literature frames them as a materials-enabled route toward less invasive and wireless control of cellular functions in vivo.
Problem solved
They address the invasiveness of conventional optogenetics, which commonly uses fiber optics positioned near the target and is described as highly invasive and problematic. The tool is therefore intended to support remote optical control in tissues such as the brain where implanted light guides are a major limitation.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A delivery strategy grouped with the mechanism branch because it determines how a system is instantiated and deployed in context.
Techniques
No technique tags yet.
Target processes
No target processes tagged yet.
Input: Light
Implementation Constraints
The evidence supports only that these are materials-based phosphors used as part of remote optical stimulation systems in living animals. Practical details such as formulation, implantation or injection strategy, tissue localization, and compatibility with specific optogenetic actuators are not provided in the supplied sources.
The provided evidence does not specify particular phosphor compositions, excitation and emission wavelengths, target opsins, or quantitative performance metrics. It also does not document independent replication, comparative efficacy, or detailed safety and delivery constraints for in vivo use.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
Conventional optogenetics commonly uses fiber optics placed close to the target, which is highly invasive and problematic.
Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers.
Conventional optogenetics commonly uses fiber optics placed close to the target, which is highly invasive and problematic.
Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers.
Conventional optogenetics commonly uses fiber optics placed close to the target, which is highly invasive and problematic.
Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers.
Conventional optogenetics commonly uses fiber optics placed close to the target, which is highly invasive and problematic.
Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers.
Conventional optogenetics commonly uses fiber optics placed close to the target, which is highly invasive and problematic.
Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers.
Conventional optogenetics commonly uses fiber optics placed close to the target, which is highly invasive and problematic.
Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers.
Conventional optogenetics commonly uses fiber optics placed close to the target, which is highly invasive and problematic.
Conventional optogenetics employs fiber optics inserted close to the target, which is highly invasive and poses various problems for researchers.
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Microbial rhodopsins used for optogenetics are sensitive to visible light.
Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum.
Microbial rhodopsins used for optogenetics are sensitive to visible light.
Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum.
Microbial rhodopsins used for optogenetics are sensitive to visible light.
Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum.
Microbial rhodopsins used for optogenetics are sensitive to visible light.
Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum.
Microbial rhodopsins used for optogenetics are sensitive to visible light.
Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum.
Microbial rhodopsins used for optogenetics are sensitive to visible light.
Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum.
Microbial rhodopsins used for optogenetics are sensitive to visible light.
Microbial rhodopsins widely used for optogenetics are sensitive to light in the visible spectrum.
Visible light delivered externally does not reach deep tissue effectively because it is heavily scattered and absorbed by tissue.
As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body.
Visible light delivered externally does not reach deep tissue effectively because it is heavily scattered and absorbed by tissue.
As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body.
Visible light delivered externally does not reach deep tissue effectively because it is heavily scattered and absorbed by tissue.
As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body.
Visible light delivered externally does not reach deep tissue effectively because it is heavily scattered and absorbed by tissue.
As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body.
Visible light delivered externally does not reach deep tissue effectively because it is heavily scattered and absorbed by tissue.
As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body.
Visible light delivered externally does not reach deep tissue effectively because it is heavily scattered and absorbed by tissue.
As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body.
Visible light delivered externally does not reach deep tissue effectively because it is heavily scattered and absorbed by tissue.
As visible light is heavily scattered and absorbed by tissue, stimulating light for optogenetic control does not reach deep in the tissue irradiated from outside the subject body.
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Approval Evidence
1 source3 linked approval claimsfirst-pass slug down-conversion-phosphors
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Source:
design goalsupports
These phosphor-based remote optogenetic methods are being explored as less invasive, wireless approaches for controlling cellular functions in the brain and other tissues.
The development of these methodologies has stimulated researchers to test novel strategies for less invasive, wireless control of cellular functions in the brain and other tissues.
Source:
remote control capabilitysupports
Up-conversion and down-conversion phosphors have enabled remote optogenetic control of neuronal activity in living animals.
Recent advances in material science integrated with neuroscience have enabled remote optogenetic control of neuronal activities in living animals using up- or down-conversion phosphors.
Source:
translational statussupports
Current phosphor-enabled remote optogenetic technologies still have limitations and require further development toward non-invasive clinical applications.
Here, we review recent reports related to these new technologies and discuss the current limitations and future perspectives toward the establishment of non-invasive optogenetics for clinical applications.
Source:
Comparisons
Source-backed strengths
The available evidence indicates that down-conversion phosphors have been explored for remote optogenetic control of neuronal activities in living animals. Their principal stated advantage is enabling wireless, less invasive light-delivery strategies relative to conventional fiber-based illumination.
Ranked Citations
- 1.