Source 1review2016Current Opinion in Pharmacology
Toolkit/engineered chimeric receptors
engineered chimeric receptors
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Engineered chimeric receptors are described as an opsin-related optical tool class for manipulating neuromodulatory GPCR signaling. They imply receptor constructs that couple light input to GPCR pathway control.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Mechanisms
light-gated control of gpcr signalingTechniques
Directed EvolutionTarget processes
recombinationsignalingInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
These optical techniques targeting specific members of the GPCR signaling pathway provide a broad base for investigating GPCR signaling in behavior and disease states and may support therapeutic development.
These emerging techniques targeting specific members of the GPCR signaling pathway offer an expansive base for investigating GPCR signaling in behavior and disease states, in addition to paving a path to potential therapeutic developments.
Optogenetics provides means to control cell signaling with spatiotemporal control in discrete cell types.
Optogenetics has revolutionized neuroscience by providing means to control cell signaling with spatiotemporal control in discrete cell types.
Cre-dependent viral vector expression and two-photon microscopy are highlighted as technologies to utilize these optical tools in vitro and in vivo.
we highlight technologies to utilize these tools in vitro and in vivo, including Cre dependent viral vector expression and two-photon microscopy
The review organizes optical manipulation of neuromodulatory GPCR signaling into four major tool classes: opsins including engineered chimeric receptors, photoactivatable proteins, photopharmacology using caged or photoswitchable molecules, and fluorescent protein-based reporters and biosensors.
we summarize four major classes of optical tools to manipulate neuromodulatory GPCR signaling: opsins (including engineered chimeric receptors); photoactivatable proteins; photopharmacology through caging-photoswitchable molecules; fluorescent protein based reporters and biosensors
Approval Evidence
1 source3 linked approval claimsfirst-pass slug engineered-chimeric-receptors
opsins (including engineered chimeric receptors)
Source:
application scopesupports
These optical techniques targeting specific members of the GPCR signaling pathway provide a broad base for investigating GPCR signaling in behavior and disease states and may support therapeutic development.
These emerging techniques targeting specific members of the GPCR signaling pathway offer an expansive base for investigating GPCR signaling in behavior and disease states, in addition to paving a path to potential therapeutic developments.
Source:
capability summarysupports
Optogenetics provides means to control cell signaling with spatiotemporal control in discrete cell types.
Optogenetics has revolutionized neuroscience by providing means to control cell signaling with spatiotemporal control in discrete cell types.
Source:
review scope summarysupports
The review organizes optical manipulation of neuromodulatory GPCR signaling into four major tool classes: opsins including engineered chimeric receptors, photoactivatable proteins, photopharmacology using caged or photoswitchable molecules, and fluorescent protein-based reporters and biosensors.
we summarize four major classes of optical tools to manipulate neuromodulatory GPCR signaling: opsins (including engineered chimeric receptors); photoactivatable proteins; photopharmacology through caging-photoswitchable molecules; fluorescent protein based reporters and biosensors
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.