Source 1review2018Stem Cells International
Toolkit/epigenome editing
epigenome editing
Also known as: epigenome editing-based therapy, epigenome-editing technologies
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Epigenome editing is a CRISPR/Cas9-based engineering approach that regulates the epigenomic state of a target genomic region to control the associated gene while causing minimal or no modification of genomic DNA. The cited literature presents it as a novel epigenetic technique and a potential therapeutic modality.
Usefulness & Problems
Why this is useful
This approach is useful for modulating gene expression through targeted control of local epigenomic state rather than altering DNA sequence. The supplied literature specifically frames epigenome-editing technologies as having potential for treatment of various diseases.
Source:
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Problem solved
Epigenome editing addresses the problem of controlling a causative gene without substantial genomic DNA sequence modification. It is positioned as a way to intervene at disease-relevant loci through targeted epigenetic regulation.
Source:
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Published Workflows
Objective: Automate molecular discovery and optimization in biofoundries by integrating AI into Design-Build-Test-Learn cycles.
Why it works: The abstract states that biofoundries integrate AI into DBTL cycles, automating molecular discovery and optimization.
AI integrationbiofoundry automationDesign-Build-Test-Learn workflow
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete method used to build, optimize, or evolve an engineered system.
Mechanisms
gene regulation without genomic dna sequence modificationreversible gene modulationrewriting of epigenetic informationtargeted regulation of epigenomic stateTarget processes
editingrecombinationselectionInput: Chemical
Implementation Constraints
The supplied evidence places epigenome editing within CRISPR/Cas9-based epigenetic techniques. Beyond that general platform assignment, the evidence does not provide construct architecture, cofactors, expression systems, or delivery details.
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy, indicating that chromatin context can constrain efficacy. The provided evidence does not specify particular effector domains, delivery strategies, target classes, or comparative success rates.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2review2023International Journal of Molecular Sciences
Ranked Claims
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Section: abstract
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Section: abstract
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Section: abstract
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Section: abstract
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Section: abstract
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Section: abstract
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Section: abstract
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Section: abstract
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Section: abstract
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Section: abstract
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Section: abstract
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Section: abstract
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Section: abstract
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Section: abstract
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Section: abstract
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Section: abstract
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Section: abstract
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Section: abstract
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Section: abstract
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Section: abstract
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Section: abstract
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Section: abstract
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Section: abstract
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Section: abstract
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Section: abstract
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Section: abstract
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Section: abstract
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Section: abstract
The emergence of CRISPR/Cas9 technology has provided new routes into the epigenetics field.
In recent years, the emergence of CRISPR/Cas9 technology has provided us with new routes to the epigenetic field.
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
Approval Evidence
3 sources8 linked approval claimsfirst-pass slug epigenome-editing
Genome-editing innovations-such as prime, base, and epigenome editing-facilitate precise and reversible modulation of psychiatric risk genes.
Source:
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases.
Source:
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing...
Source:
application scopesupports
Design biology advances including artificial cells, DNA nanostructures, AI-driven molecular design, biofoundries, and next-generation genome editing are transforming mind-body health sciences.
Source:
capabilitysupports
Prime editing, base editing, and epigenome editing facilitate precise and reversible modulation of psychiatric risk genes.
Source:
contextual combinationsupports
The utility of next-generation genome editing for psychiatric risk gene modulation is particularly highlighted when combined with iPSC and brain-organoid models.
Source:
design considerationsupports
Chromatin plasticity is identified as an important factor for more effective epigenome editing-based therapy.
introduce important factors to consider, such as chromatin plasticity, for a more effective epigenome editing-based therapy
Source:
mechanistic rationalesupports
Epigenome editing can regulate the epigenomic state of a target region and thereby the causative gene with minimal or no modification of genomic DNA.
it can regulate the expression of the epigenome of the target region, and thereby the causative gene, with minimal or no modification of the genomic DNA
Source:
therapeutic potentialsupports
Epigenome editing is presented as a potential therapeutic approach for various diseases, including rare imprinted diseases.
The advancement in epigenetics research over the past several decades has led to the potential application of epigenome-editing technologies for the treatment of various diseases. In particular, epigenome editing is potentially useful in the treatment of genetic and other related diseases, including rare imprinted diseases
Source:
translation challengesupports
Successful in vivo therapeutic application of epigenome editing requires improvements in target specificity, enzymatic activity, and drug delivery.
Various efforts are underway to successfully apply epigenome editing in vivo, such as improving target specificity, enzymatic activity, and drug delivery for the development of reliable therapeutics.
Source:
review scopesupports
The review covers CRISPR/Cas9-based epigenetic techniques including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
In this review, novel epigenetic techniques utilizing the CRISPR/Cas9 system are the main contents to be discussed, including epigenome editing, temporal and spatial control of epigenetic effectors, noncoding RNA manipulation, chromatin in vivo imaging, and epigenetic element screening.
Source:
Comparisons
Source-backed strengths
A key stated advantage is regulation of a target region's epigenomic state with minimal or no modification of genomic DNA. The literature also identifies therapeutic potential across various diseases, but the supplied evidence does not provide quantitative performance data or specific disease validations.
Ranked Citations
- 1.
- 2.