Source 1review2021Chemical Science
Toolkit/heteroleptic coordination cage
heteroleptic coordination cage
Also known as: heteroleptic cage, heteroleptic structure
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
This review showcases the implementation of function into self-assembled cages and devises strategies to selectively form heteroleptic structures.
Usefulness & Problems
Why this is useful
Heteroleptic coordination cages combine more than one ligand or functional component within the same self-assembled host. The review presents them as a route to higher structural and functional complexity.; combining more than one function within the same assembly; building multifunctional host systems without statistical mixtures
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Heteroleptic coordination cages combine more than one ligand or functional component within the same self-assembled host. The review presents them as a route to higher structural and functional complexity.
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combining more than one function within the same assembly
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building multifunctional host systems without statistical mixtures
Problem solved
They address the need to place multiple functions into one assembly rather than relying on single-component homoleptic systems. This is framed as important for enzyme-like multifunctionality.; enabling multicomponent multifunctionality in a single cage assembly; supporting selective formation of mixed-component cage structures
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They address the need to place multiple functions into one assembly rather than relying on single-component homoleptic systems. This is framed as important for enzyme-like multifunctionality.
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enabling multicomponent multifunctionality in a single cage assembly
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supporting selective formation of mixed-component cage structures
Problem links
enabling multicomponent multifunctionality in a single cage assembly
LiteratureThey address the need to place multiple functions into one assembly rather than relying on single-component homoleptic systems. This is framed as important for enzyme-like multifunctionality.
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They address the need to place multiple functions into one assembly rather than relying on single-component homoleptic systems. This is framed as important for enzyme-like multifunctionality.
supporting selective formation of mixed-component cage structures
LiteratureThey address the need to place multiple functions into one assembly rather than relying on single-component homoleptic systems. This is framed as important for enzyme-like multifunctionality.
Source:
They address the need to place multiple functions into one assembly rather than relying on single-component homoleptic systems. This is framed as important for enzyme-like multifunctionality.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A reusable architecture pattern for arranging parts into an engineered system.
Mechanisms
host-guest complex formationselective molecular recognitionself-assemblystimulus-responsive switchingTechniques
No technique tags yet.
Target processes
recombinationImplementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: regulator
The abstract supports a need for sophisticated assembly strategies to selectively form these structures. Specific design rules or component sets are not provided in the supplied text.; requires assembly strategies that selectively form heteroleptic structures; must control multicomponent self-assembly to avoid statistical mixtures
The abstract does not support that heteroleptic assembly alone guarantees useful function. It also does not remove the risk of statistical mixtures unless selective strategies are used.; selective formation is challenging; avoiding statistical mixtures requires sophisticated assembly strategies
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Multicomponent multifunctional host-guest complexes are presented as early examples with potential applications in sensing, catalysis, and photo-redox systems.
We discuss first examples resulting from a combination of both principles, namely multicomponent multifunctional host-guest complexes, and their potential in application in areas such as sensing, catalysis, and photo-redox systems.
Combining several functionalities within the same assembly without creating statistical mixtures requires sophisticated assembly strategies.
Combining several functionalities without creating statistical mixtures, however, requires a toolbox of sophisticated assembly strategies.
Dedicated functionalities such as catalytic centres or photoswitches have been implemented in coordination cages to enable stimuli control and expanded function.
Recently, the field has made big steps forward by implementing dedicated functionality, e.g. catalytic centres or photoswitches to allow stimuli control.
Self-assembled coordination cages have attracted growing attention because their nano-scale cavities enable host functions such as selective recognition and confined reaction environments.
cages, with particularly the latter ones catching growing attention, owing to their nano-scale cavities. Assemblies serving as hosts allow application as selective receptors, confined reaction environments and more.
Approval Evidence
1 source1 linked approval claimfirst-pass slug heteroleptic-coordination-cage
This review showcases the implementation of function into self-assembled cages and devises strategies to selectively form heteroleptic structures.
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design challengesupports
Combining several functionalities within the same assembly without creating statistical mixtures requires sophisticated assembly strategies.
Combining several functionalities without creating statistical mixtures, however, requires a toolbox of sophisticated assembly strategies.
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Comparisons
Source-stated alternatives
The review contrasts heteroleptic structures with homoleptic systems composed of one type of ligand. It also discusses combining heteroleptic assembly with functional implementation.
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The review contrasts heteroleptic structures with homoleptic systems composed of one type of ligand. It also discusses combining heteroleptic assembly with functional implementation.
Source-backed strengths
supports inclusion of more than one function within the same assembly; aligned with enzyme-inspired organization of recognition, regulation, and reaction functions
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supports inclusion of more than one function within the same assembly
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aligned with enzyme-inspired organization of recognition, regulation, and reaction functions
heteroleptic coordination cage and cell-specific receptor subtype gene deletion mouse models address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Strengths here: looks easier to implement in practice.
heteroleptic coordination cage and CheRiff + jRCaMP1b + RH237 cardiac all-optical electrophysiology platform address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Strengths here: looks easier to implement in practice.
Compared with eNpHR
heteroleptic coordination cage and eNpHR address a similar problem space because they share recombination.
Shared frame: same top-level item type; shared target processes: recombination
Strengths here: looks easier to implement in practice; may avoid an exogenous cofactor requirement.
Ranked Citations
- 1.