Source 1review2018Materials
Toolkit/implantable optical fibers
implantable optical fibers
Also known as: optical fibers
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
By delivering light into deep tissue via these devices, novel applications including biological sensing, stimulation and therapy can be realized. Therefore, implantable fibers ... in biocompatible formats with versatile functionalities are highly desirable.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Published Workflows
Illuminating the Undergraduate Behavioral Neuroscience Laboratory: A Guide for the in vivo Application of Optogenetics in Mammalian Model Organisms.
2016Objective: Establish in vivo optogenetics with rodents in an undergraduate laboratory setting while improving financial accessibility.
Why it works: The abstract presents the setup as a combination of coordinated design choices spanning actuator selection, targeting strategy, model choice, experiment design, and light delivery hardware, with cost-saving guidance intended to make the overall approach accessible.
opsin-based optical control in rodentscell-specific opsin expressionopsin selectionspecies selectionexperimental designlight delivery system selectionconstruction of implantable optical fibers
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A delivery strategy grouped with the mechanism branch because it determines how a system is instantiated and deployed in context.
Target processes
recombinationselectionInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2primary paper2016PubMed
Source 3review2013Behavioural Brain Research
Ranked Claims
Delivering light into deep tissue via implantable optical fibers and waveguides can enable biological sensing, stimulation, and therapy.
By delivering light into deep tissue via these devices, novel applications including biological sensing, stimulation and therapy can be realized.
Biocompatible implantable fibers and waveguides with versatile functionalities are highly desirable for biomedical use.
Therefore, implantable fibers and waveguides in biocompatible formats with versatile functionalities are highly desirable.
Newly developed fiber- and waveguide-based devices are presented as playing a crucial role in advanced optical biointerfaces.
We believe that these newly developed fiber and waveguide based devices play a crucial role in advanced optical biointerfaces.
The review covers materials design and fabrication strategies for implantable optical fibers and waveguides and discusses applications in light therapy, optogenetics, fluorescence sensing, and imaging.
Specifically, we highlight novel materials design and fabrication strategies to form implantable fibers and waveguides. Furthermore, their applications in various biomedical fields such as light therapy, optogenetics, fluorescence sensing and imaging are discussed.
Optical fibers and waveguides effectively control and modulate light propagation and are receiving increasing attention in biomedical applications.
Optical fibers and waveguides in general effectively control and modulate light propagation... Recently, they have received increasing attention in biomedical applications.
Little to no work has focused on bringing optogenetics to mammalian model organisms in undergraduate neuroscience laboratories.
While there has been a significant body of work concentrated to deploy optogenetics in invertebrate model organisms, little to no work has focused on brining this technology to mammalian model organisms in undergraduate neuroscience laboratories.
Optogenetics is a rapidly growing neuroscience technology that has established itself as a fundamental investigative tool.
Optogenetics is a technology that is growing rapidly in neuroscience, establishing itself as a fundamental investigative tool.
The paper discusses opsin selection, cell-specific opsin expression strategies, species selection, experimental design, light delivery system selection, and construction of implantable optical fibers for rodent in vivo optogenetics.
We discuss opsin selection, cell-specific opsin expression strategies, species selection, experimental design, selection of light delivery systems, and the construction of implantable optical fibers for the application of in vivo optogenetics in rodents.
Establishing in vivo optogenetics could enable high-impact independent research projects for upper-level undergraduate students.
The establishment of in vivo optogenetics could provide for high-impact independent research projects for upper-level undergraduate students.
Long-term in vivo optogenetic studies in this review context rely on implantable optical-fiber strategies for light delivery.
Projection-specific optogenetic manipulation is presented as a central strategy for dissecting stress-related circuitry.
The review discusses promoter-based targeting such as CaMKIIα to enrich opsin delivery to selected neuronal populations.
The review discusses both excitatory and inhibitory optogenetic actuators for causal manipulation of stress-related neural circuits.
Approval Evidence
3 sources7 linked approval claimsfirst-pass slug implantable-optical-fibers
By delivering light into deep tissue via these devices, novel applications including biological sensing, stimulation and therapy can be realized. Therefore, implantable fibers ... in biocompatible formats with versatile functionalities are highly desirable.
Source:
We discuss opsin selection, cell-specific opsin expression strategies, species selection, experimental design, selection of light delivery systems, and the construction of implantable optical fibers for the application of in vivo optogenetics in rodents.
Source:
The supplied web research summary identifies implantable optical fibers as an explicitly supported hardware/protocol component for long-term in vivo optogenetic manipulation cited by the review.
Source:
application scopesupports
Delivering light into deep tissue via implantable optical fibers and waveguides can enable biological sensing, stimulation, and therapy.
By delivering light into deep tissue via these devices, novel applications including biological sensing, stimulation and therapy can be realized.
Source:
design needsupports
Biocompatible implantable fibers and waveguides with versatile functionalities are highly desirable for biomedical use.
Therefore, implantable fibers and waveguides in biocompatible formats with versatile functionalities are highly desirable.
Source:
field significancesupports
Newly developed fiber- and waveguide-based devices are presented as playing a crucial role in advanced optical biointerfaces.
We believe that these newly developed fiber and waveguide based devices play a crucial role in advanced optical biointerfaces.
Source:
review coveragesupports
The review covers materials design and fabrication strategies for implantable optical fibers and waveguides and discusses applications in light therapy, optogenetics, fluorescence sensing, and imaging.
Specifically, we highlight novel materials design and fabrication strategies to form implantable fibers and waveguides. Furthermore, their applications in various biomedical fields such as light therapy, optogenetics, fluorescence sensing and imaging are discussed.
Source:
review scope summarysupports
Optical fibers and waveguides effectively control and modulate light propagation and are receiving increasing attention in biomedical applications.
Optical fibers and waveguides in general effectively control and modulate light propagation... Recently, they have received increasing attention in biomedical applications.
Source:
scope statementsupports
The paper discusses opsin selection, cell-specific opsin expression strategies, species selection, experimental design, light delivery system selection, and construction of implantable optical fibers for rodent in vivo optogenetics.
We discuss opsin selection, cell-specific opsin expression strategies, species selection, experimental design, selection of light delivery systems, and the construction of implantable optical fibers for the application of in vivo optogenetics in rodents.
Source:
implementation supportsupports
Long-term in vivo optogenetic studies in this review context rely on implantable optical-fiber strategies for light delivery.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
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