Toolkit/in silico feedback control strategies

in silico feedback control strategies

Engineering Method·Research·Since 2022

Also known as: computer-controlled living systems, feedback control

Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.

Summary

In silico feedback control strategies are computationally implemented control schemes coupled to optogenetic measurement and light stimulation platforms. They are used to create computer-controlled living systems through automated measurement and stimulation workflows.

Usefulness & Problems

Why this is useful

These strategies are useful for closing the loop between biological measurement and optical actuation in living systems. The cited review indicates that they operate across optogenetic platforms spanning different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

Source:

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination

Problem solved

They address the problem of implementing real-time control over living systems using automated experimental platforms. Specifically, the review states that automated measurement and stimulation schemes enabled feedback control strategies in optogenetic systems.

Source:

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination

Problem links

Synthetic Biology Platforms Are Over-Reliant on Evolved Cells That We Don’t Fully Understand or Control

Gap mapView gap

Computer-controlled feedback strategies could partially compensate for the unpredictability of evolved cells by imposing external control over living systems. That makes it a plausible control-layer method for the gap, even though it does not itself provide a bottom-up cell chassis.

Challenges in Tracking and Restoring Resilient Ecosystems

Gap mapView gap

The gap highlights feedback loops and the need to experiment with restoration strategies. In silico feedback control could plausibly inform closed-loop experimental designs or adaptive interventions, but the supplied evidence is from computer-controlled living systems rather than ecosystems.

Understanding Life as a Far-From-Equilibrium Physical Phenomenon

Gap mapView gap

Closed-loop control of living systems can be useful for probing nonequilibrium dynamics and testing whether proposed physical descriptors predict system behavior under perturbation. It is more relevant as an experimental framework for interrogating dynamical properties than as a direct formal theory.

Taxonomy & Function

Primary hierarchy

Technique Branch

Method: A concrete method used to build, optimize, or evolve an engineered system.

Target processes

No target processes tagged yet.

Input: Light

Implementation Constraints

cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: spectral hardware requirementoperating role: builder

Implementation requires an optogenetic platform with automated measurement and light-based stimulation capabilities. The supplied evidence supports use across different cell types and culture volumes, but it does not specify hardware configurations, genetic constructs, wavelengths, or software architectures.

The provided evidence is limited to a review-level statement that such strategies have been enabled by automated optogenetic platforms. No specific control algorithms, performance metrics, or comparative validation data are provided in the supplied evidence.

Validation

Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication

Supporting Sources

Ranked Claims

Claim 1application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 2application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 3application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 4application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 5application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 6application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 7application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 8application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 9application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 10application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 11application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 12application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 13application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 14application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 15application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 16application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 17application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 18application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 19application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 20application spansupports2022Source 1needs review

Optogenetic experiment platform designs in the review span different cell types and culture volumes, from single-cell stimulation to whole-culture illumination.

we examine design approaches followed in performing optogenetic experiments spanning different cell types and culture volumes, with induction capabilities ranging from single cell stimulation to entire cell culture illumination
Claim 21automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 22automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 23automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 24automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 25automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 26automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 27automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 28automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 29automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 30automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 31automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 32automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 33automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 34automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 35automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 36automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 37automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 38automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 39automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 40automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 41automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 42automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 43automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 44automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 45automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 46automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 47automation enables controlsupports2022Source 1needs review

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems
Claim 48design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 49design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 50design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 51design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 52design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 53design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 54design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 55design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 56design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 57design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 58design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 59design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 60design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 61design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 62design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 63design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 64design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 65design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 66design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 67design requirementsupports2022Source 1needs review

Emerging optogenetic applications require light delivery that is consistent, reproducible, and regulated according to application needs.

Emerging optogenetic applications entail a consistent, reproducible, and regulated delivery of light adapted to the application requirement.
Claim 68platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 69platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 70platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 71platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 72platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 73platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 74platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 75platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 76platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 77platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 78platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 79platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 80platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 81platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 82platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 83platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 84platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 85platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 86platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 87platform rangesupports2022Source 1needs review

The review covers optogenetic stimulation platform designs ranging from simple illumination set-ups to microscopy, microtiter plate, and bioreactor designs, each with advantages and disadvantages.

we explore the evolution of light-induction hardware-software platforms from simple illumination set-ups to sophisticated microscopy, microtiter plate and bioreactor designs, and discuss their respective advantages and disadvantages
Claim 88review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 89review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 90review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 91review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 92review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 93review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 94review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 95review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 96review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 97review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 98review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 99review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 100review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 101review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 102review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 103review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 104review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 105review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 106review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.
Claim 107review scope summarysupports2022Source 1needs review

Suitable light stimulation platforms are required to stimulate synthetic optogenetic constructs in biological systems.

Light stimulation of a synthetic optogenetic construct in a given biological species can only be achieved via a suitable light stimulation platform.

Approval Evidence

1 source1 linked approval claimfirst-pass slug in-silico-feedback-control-strategies
The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems

Source:

automation enables controlsupports

Automated measurement and stimulation schemes on optogenetic platforms have enabled implementation of in silico feedback control strategies for computer-controlled living systems.

The development of automated measurement and stimulation schemes on these platforms has enabled researchers to implement various in silico feedback control strategies to achieve computer-controlled living systems

Source:

Comparisons

Source-backed strengths

A key strength is compatibility with automated optogenetic platforms that integrate measurement and stimulation. The reviewed platform designs span multiple biological contexts and scales, including different cell types and culture volumes from single cells to whole cultures.

in silico feedback control strategies and automated optogenetic feedback control address a similar problem space.

Shared frame: same top-level item type; shared mechanisms: feedback control; same primary input modality: light

in silico feedback control strategies and doxycycline-dependent photoactivated gene expression address a similar problem space.

Shared frame: same top-level item type; same primary input modality: light

in silico feedback control strategies and oligomerization reactions address a similar problem space.

Shared frame: same top-level item type; same primary input modality: light

Ranked Citations

  1. 1.
    StructuralSource 1Frontiers in Bioengineering and Biotechnology2022Claim 19Claim 20Claim 19

    Seeded from load plan for claim c5. Extracted from this source document.