Source 1review2021Advances in experimental medicine and biology
Toolkit/light-driven ion pump rhodopsins
light-driven ion pump rhodopsins
Also known as: ion-pumping rhodopsins, light-driven ion-pumping rhodopsins
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Ion-transporting microbial rhodopsins are widely used as major molecular tools in optogenetics... light-driven ion pumps actively transport specific ions, such as H+, Na+, Cl-, against electrophysiological potential by using light energy... light-driven ion-pumping rhodopsins are mostly applied as inhibitory optogenetics tools.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level protein part used inside a larger architecture that realizes a mechanism.
Techniques
Sequence VerificationTarget processes
No target processes tagged yet.
Input: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Light-driven ion-pumping rhodopsins are mostly applied as inhibitory optogenetics tools.
Ion-transporting microbial rhodopsins are widely used as molecular tools in optogenetics.
Genome and metagenome sequencing have identified several thousand ion-pumping rhodopsins from diverse microbes, and functional characterization has been revealing new pump types.
Ion transport by light-driven ion-pump rhodopsins induces membrane hyperpolarization and inhibits neural firing.
Light-driven ion pumps actively transport specific ions including H+, Na+, and Cl- using light energy, in contrast to light-gated ion channels that passively transport ions.
Approval Evidence
1 source5 linked approval claimsfirst-pass slug light-driven-ion-pump-rhodopsins
Ion-transporting microbial rhodopsins are widely used as major molecular tools in optogenetics... light-driven ion pumps actively transport specific ions, such as H+, Na+, Cl-, against electrophysiological potential by using light energy... light-driven ion-pumping rhodopsins are mostly applied as inhibitory optogenetics tools.
Source:
application scopesupports
Light-driven ion-pumping rhodopsins are mostly applied as inhibitory optogenetics tools.
Source:
application summarysupports
Ion-transporting microbial rhodopsins are widely used as molecular tools in optogenetics.
Source:
discovery landscapesupports
Genome and metagenome sequencing have identified several thousand ion-pumping rhodopsins from diverse microbes, and functional characterization has been revealing new pump types.
Source:
functional effectsupports
Ion transport by light-driven ion-pump rhodopsins induces membrane hyperpolarization and inhibits neural firing.
Source:
mechanism summarysupports
Light-driven ion pumps actively transport specific ions including H+, Na+, and Cl- using light energy, in contrast to light-gated ion channels that passively transport ions.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.