Source 1primary paper2018Advanced Materials
Toolkit/light pulse-counting materials system
light pulse-counting materials system
Also known as: biohybrid materials system, materials system that counts light pulses
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The light pulse-counting materials system is a biohybrid polymer framework assembled from synthetic biology-derived modules that detects the number of input light pulses. It releases distinct output molecules as a function of pulse count.
Usefulness & Problems
Why this is useful
This system is useful as a material that performs light-dependent input processing rather than simple on/off actuation. The reported design shows that synthetic biology switch principles can be transferred into polymer materials to encode pulse-number-specific outputs.
Source:
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Source:
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
Problem solved
It addresses the problem of building materials that discriminate between different temporal patterns of optical stimulation, specifically the number of light pulses. The system solves this by coupling light detection to pulse-count-dependent release of distinct molecules from a polymer framework.
Source:
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Techniques
Computational DesignTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
The system is implemented as a polymer framework containing combined synthetic biology-derived functional modules. A quantitative mathematical model guided module combination, but the available evidence does not describe construct architecture, cofactors, fabrication conditions, or delivery constraints.
The supplied evidence does not specify the molecular identity of the light-responsive modules, the released outputs, the wavelengths used, or quantitative performance metrics such as dynamic range, counting fidelity, or response time. Independent replication and validation outside the cited report are not documented in the provided evidence.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Approval Evidence
1 source4 linked approval claimsfirst-pass slug light-pulse-counting-materials-system
This is exemplified by the synthesis of a materials system that counts light pulses. Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
Source:
applicationsupports
Synthetic biology switches and design principles were applied to synthesize multi-input-processing materials.
Here, the concept is introduced to apply synthetic biology switches and design principles for the synthesis of multi-input-processing materials.
Source:
design guidancesupports
A quantitative mathematical model guided the combination of synthetic biology-derived modules into the polymer framework.
Guided by a quantitative mathematical model, functional synthetic biology-derived modules are combined into a polymer framework
Source:
functional capabilitysupports
A biohybrid materials system built from synthetic biology-derived modules in a polymer framework releases distinct output molecules according to the number of input light pulses detected.
functional synthetic biology-derived modules are combined into a polymer framework resulting in a biohybrid materials system that releases distinct output molecules specific to the number of input light pulses detected.
Source:
modular extensionsupports
Modular extension yielded a light pulse-counting materials system that sequentially releases different enzymes catalyzing a multistep biochemical reaction.
Further demonstration of modular extension yields a light pulse-counting materials system to sequentially release different enzymes catalyzing a multistep biochemical reaction.
Source:
Comparisons
Source-backed strengths
A key strength is that the material does not merely respond to light presence, but distinguishes pulse number and maps it to different released outputs. Its construction was guided by a quantitative mathematical model, providing an explicit design framework for combining functional modules in the polymer material.
Ranked Citations
- 1.