Source 1review2024Journal of Biological Chemistry
Toolkit/LOVS1K
LOVS1K
Also known as: LOVS1K
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The supplied web research summary states that the anchor review explicitly lists LOVS1K as a named LOV2-based calcium actuator.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Mechanisms
OligomerizationTechniques
Computational DesignTarget processes
signalingInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2review2021Cells
Ranked Claims
The review scaffold groups STIM1 optogenetic tools into at least CRY2-based oligomerization designs and LOV2-based unfolding or caging designs for optical control of calcium signaling.
The review scaffold explicitly names OptoSTIM1, monSTIM1, eOS1, Opto-CRAC1, Opto-CRAC2, BACCS, and LOVS1K as STIM1-related optogenetic calcium-control tools or variants within the review scope.
The review covers optogenetic tools for precise control of Ca2+-permeable ion channels, receptors, and associated downstream signaling cascades.
Here, we review the various optogenetic tools that have been used to achieve precise control over different Ca2+-permeable ion channels and receptors and associated downstream signaling cascades.
Approval Evidence
2 sources3 linked approval claimsfirst-pass slug lovs1k
The supplied web research summary states that the anchor review explicitly lists LOVS1K as a named LOV2-based calcium actuator.
Source:
Web research summary lists LOVS1K as an explicitly identified predecessor/comparator optogenetic Ca2+ control tool relevant to this review.
Source:
design mechanism summarysupports
The review scaffold groups STIM1 optogenetic tools into at least CRY2-based oligomerization designs and LOV2-based unfolding or caging designs for optical control of calcium signaling.
Source:
tool family membershipsupports
The review scaffold explicitly names OptoSTIM1, monSTIM1, eOS1, Opto-CRAC1, Opto-CRAC2, BACCS, and LOVS1K as STIM1-related optogenetic calcium-control tools or variants within the review scope.
Source:
review scope statementsupports
The review covers optogenetic tools for precise control of Ca2+-permeable ion channels, receptors, and associated downstream signaling cascades.
Here, we review the various optogenetic tools that have been used to achieve precise control over different Ca2+-permeable ion channels and receptors and associated downstream signaling cascades.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.
- 2.