Source 1primary paper2025MED
Toolkit/MR-guided focused ultrasound
MR-guided focused ultrasound
Also known as: focused ultrasound therapy, MRgFUS
Taxonomy: Technique Branch / Method. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
MR-guided focused ultrasound has emerged as an incisionless and minimally invasive neurofunctional treatment.
Usefulness & Problems
Why this is useful
MR-guided focused ultrasound is presented as an incisionless neurofunctional treatment. In high-intensity mode it produces therapeutic thermoablation, and in low-intensity mode it can induce mechanical effects including transient blood-brain barrier opening and neuromodulation.; incisionless neurofunctional treatment for movement disorders; therapeutic thermoablation; blood-brain barrier opening; neuromodulation
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MR-guided focused ultrasound is presented as an incisionless neurofunctional treatment. In high-intensity mode it produces therapeutic thermoablation, and in low-intensity mode it can induce mechanical effects including transient blood-brain barrier opening and neuromodulation.
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incisionless neurofunctional treatment for movement disorders
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therapeutic thermoablation
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blood-brain barrier opening
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neuromodulation
Problem solved
The modality addresses the need for minimally invasive treatment options for movement disorders. It is positioned as an alternative to more invasive functional neurosurgical approaches.; provides a minimally invasive alternative to functional neurosurgical intervention
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The modality addresses the need for minimally invasive treatment options for movement disorders. It is positioned as an alternative to more invasive functional neurosurgical approaches.
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provides a minimally invasive alternative to functional neurosurgical intervention
Problem links
provides a minimally invasive alternative to functional neurosurgical intervention
LiteratureThe modality addresses the need for minimally invasive treatment options for movement disorders. It is positioned as an alternative to more invasive functional neurosurgical approaches.
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The modality addresses the need for minimally invasive treatment options for movement disorders. It is positioned as an alternative to more invasive functional neurosurgical approaches.
Taxonomy & Function
Primary hierarchy
Technique Branch
Method: A concrete measurement method used to characterize an engineered system.
Techniques
Functional AssayTarget processes
No target processes tagged yet.
Implementation Constraints
cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationoperating role: sensor
The abstract supports that the approach requires MRI guidance and focused ultrasound energy delivery. Different applications depend on using either high-intensity or low-intensity ultrasound modalities.; requires MRI guidance; requires ultrasound energy delivery to brain tissue; high-intensity use is tied to thermoablation while low-intensity use is tied to mechanical effects
The abstract does not establish broad efficacy across all movement disorders or neurodegenerative diseases. For dystonia and tremor of other origin, it says only that applications have been preliminarily investigated.; evidence in the abstract is indication-dependent; other indications are described only as preliminarily investigated; future role in neurodegenerative diseases is presented as prospective rather than established
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Randomized controlled trials have shown safety and symptomatic efficacy of focused ultrasound ablation, particularly in essential tremor and Parkinson's disease.
Several randomised controlled trials have shown safety and symptomatic efficacy of focused ultrasound ablation, particularly to treat patients with essential tremor or Parkinson's disease.
MR-guided focused ultrasound might have an important future role in treating movement disorders and neurodegenerative diseases.
Therefore, MR-guided focused ultrasound might have an important role in the future treatment of patients with movement disorders and neurodegenerative diseases.
Focused ultrasound therapy has been preliminarily investigated for tremor of other origin and dystonia.
its application for other indications-such as tremor of other origin and dystonia-has also been preliminarily investigated
High-intensity MR-guided focused ultrasound produces therapeutic thermoablation.
This new approach is based on the delivery of high-intensity ultrasound energy to produce therapeutic thermoablation.
Low-intensity MR-guided focused ultrasound can produce mechanical effects on brain tissue including transient blood-brain barrier opening and neuromodulation.
MR-guided focused ultrasound has been explored in the modality of low-intensity ultrasound, which allows mechanical effects on brain tissue, primarily transient blood-brain barrier opening and neuromodulation
MR-guided focused ultrasound has emerged as an incisionless and minimally invasive neurofunctional treatment for movement disorders.
MR-guided focused ultrasound has emerged as an incisionless and minimally invasive neurofunctional treatment.
Approval Evidence
1 source6 linked approval claimsfirst-pass slug mr-guided-focused-ultrasound
MR-guided focused ultrasound has emerged as an incisionless and minimally invasive neurofunctional treatment.
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clinical evidencesupports
Randomized controlled trials have shown safety and symptomatic efficacy of focused ultrasound ablation, particularly in essential tremor and Parkinson's disease.
Several randomised controlled trials have shown safety and symptomatic efficacy of focused ultrasound ablation, particularly to treat patients with essential tremor or Parkinson's disease.
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future potentialsupports
MR-guided focused ultrasound might have an important future role in treating movement disorders and neurodegenerative diseases.
Therefore, MR-guided focused ultrasound might have an important role in the future treatment of patients with movement disorders and neurodegenerative diseases.
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indication expansionsupports
Focused ultrasound therapy has been preliminarily investigated for tremor of other origin and dystonia.
its application for other indications-such as tremor of other origin and dystonia-has also been preliminarily investigated
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mechanism of actionsupports
High-intensity MR-guided focused ultrasound produces therapeutic thermoablation.
This new approach is based on the delivery of high-intensity ultrasound energy to produce therapeutic thermoablation.
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mechanistic capabilitysupports
Low-intensity MR-guided focused ultrasound can produce mechanical effects on brain tissue including transient blood-brain barrier opening and neuromodulation.
MR-guided focused ultrasound has been explored in the modality of low-intensity ultrasound, which allows mechanical effects on brain tissue, primarily transient blood-brain barrier opening and neuromodulation
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therapeutic positioningsupports
MR-guided focused ultrasound has emerged as an incisionless and minimally invasive neurofunctional treatment for movement disorders.
MR-guided focused ultrasound has emerged as an incisionless and minimally invasive neurofunctional treatment.
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Comparisons
Source-stated alternatives
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
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Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Source-backed strengths
incisionless; minimally invasive; supported by randomized controlled trial evidence for safety and symptomatic efficacy in some indications
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incisionless
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minimally invasive
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supported by randomized controlled trial evidence for safety and symptomatic efficacy in some indications
Compared with brain stimulation
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Shared frame: source-stated alternative in extracted literature
Strengths here: incisionless; minimally invasive; supported by randomized controlled trial evidence for safety and symptomatic efficacy in some indications.
Relative tradeoffs: evidence in the abstract is indication-dependent; other indications are described only as preliminarily investigated; future role in neurodegenerative diseases is presented as prospective rather than established.
Source:
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Compared with Deep Brain Stimulation
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Shared frame: source-stated alternative in extracted literature
Strengths here: incisionless; minimally invasive; supported by randomized controlled trial evidence for safety and symptomatic efficacy in some indications.
Relative tradeoffs: evidence in the abstract is indication-dependent; other indications are described only as preliminarily investigated; future role in neurodegenerative diseases is presented as prospective rather than established.
Source:
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Compared with focused ultrasound
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Shared frame: source-stated alternative in extracted literature
Strengths here: incisionless; minimally invasive; supported by randomized controlled trial evidence for safety and symptomatic efficacy in some indications.
Relative tradeoffs: evidence in the abstract is indication-dependent; other indications are described only as preliminarily investigated; future role in neurodegenerative diseases is presented as prospective rather than established.
Source:
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Compared with ultrasonography
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Shared frame: source-stated alternative in extracted literature
Strengths here: incisionless; minimally invasive; supported by randomized controlled trial evidence for safety and symptomatic efficacy in some indications.
Relative tradeoffs: evidence in the abstract is indication-dependent; other indications are described only as preliminarily investigated; future role in neurodegenerative diseases is presented as prospective rather than established.
Source:
Deep brain stimulation is explicitly mentioned as an established functional neurosurgery option. The abstract contrasts ablative high-intensity focused ultrasound with low-intensity focused ultrasound applications.
Ranked Citations
- 1.