Source 1review2019Advanced Healthcare Materials
Toolkit/Near-infrared-light activatable nanoparticles
Near-infrared-light activatable nanoparticles
Also known as: NIR-activatable nanomaterials, NIR-activatable optogenetic tools
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Near-infrared-light activatable nanoparticles are nanomaterial-based optogenetic delivery harnesses designed for deep-tissue-penetrating wireless optical control. They are described as enabling low-invasive remote activation and inhibition of cellular signaling pathways under near-infrared light.
Usefulness & Problems
Why this is useful
This tool class is useful because it is intended to extend optogenetic control beyond the shallow tissue penetration limits of visible light. The cited source describes these nanoparticles as supporting low-invasive remote control of cellular signaling pathways in deep tissues.
Source:
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
Problem solved
Conventional optogenetic tools generally depend on visible light, which has shallow tissue penetration. They also often require invasive fiber-optic probe delivery into organs and animal tissues, a limitation these near-infrared-activatable nanoparticles are described as addressing.
Source:
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A delivery strategy grouped with the mechanism branch because it determines how a system is instantiated and deployed in context.
Techniques
No technique tags yet.
Target processes
recombinationsignalingInput: Light
Implementation Constraints
The available evidence supports only that these are nanomaterial-based systems actuated by near-infrared light for wireless optogenetic control. No construct design, cofactor requirements, delivery route, expression system, or formulation details are specified in the supplied material.
The provided evidence is limited to high-level application and motivation statements from a single source. No specific nanoparticle composition, optical parameters, target proteins, recombination use case, or quantitative performance metrics are provided here.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
A second major class of NIR-activatable optogenetic tools couples an NIR absorber to heat generation for activation of thermosensitive proteins.
the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins
A second major class of NIR-activatable optogenetic tools couples an NIR absorber to heat generation for activation of thermosensitive proteins.
the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins
A second major class of NIR-activatable optogenetic tools couples an NIR absorber to heat generation for activation of thermosensitive proteins.
the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins
A second major class of NIR-activatable optogenetic tools couples an NIR absorber to heat generation for activation of thermosensitive proteins.
the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins
A second major class of NIR-activatable optogenetic tools couples an NIR absorber to heat generation for activation of thermosensitive proteins.
the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins
A second major class of NIR-activatable optogenetic tools couples an NIR absorber to heat generation for activation of thermosensitive proteins.
the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins
A second major class of NIR-activatable optogenetic tools couples an NIR absorber to heat generation for activation of thermosensitive proteins.
the other type couples with an NIR absorber to convert NIR light to heat to activate thermosensitive proteins
One major class of NIR-activatable optogenetic tools uses lanthanide-doped upconversion nanoparticles to convert NIR light into visible light for modulation of classical opsin-expressing neurons.
one uses lanthanide-doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin-expressing neurons
One major class of NIR-activatable optogenetic tools uses lanthanide-doped upconversion nanoparticles to convert NIR light into visible light for modulation of classical opsin-expressing neurons.
one uses lanthanide-doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin-expressing neurons
One major class of NIR-activatable optogenetic tools uses lanthanide-doped upconversion nanoparticles to convert NIR light into visible light for modulation of classical opsin-expressing neurons.
one uses lanthanide-doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin-expressing neurons
One major class of NIR-activatable optogenetic tools uses lanthanide-doped upconversion nanoparticles to convert NIR light into visible light for modulation of classical opsin-expressing neurons.
one uses lanthanide-doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin-expressing neurons
One major class of NIR-activatable optogenetic tools uses lanthanide-doped upconversion nanoparticles to convert NIR light into visible light for modulation of classical opsin-expressing neurons.
one uses lanthanide-doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin-expressing neurons
One major class of NIR-activatable optogenetic tools uses lanthanide-doped upconversion nanoparticles to convert NIR light into visible light for modulation of classical opsin-expressing neurons.
one uses lanthanide-doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin-expressing neurons
One major class of NIR-activatable optogenetic tools uses lanthanide-doped upconversion nanoparticles to convert NIR light into visible light for modulation of classical opsin-expressing neurons.
one uses lanthanide-doped upconversion nanoparticles to transduce NIR light to visible light to modulate classical opsin-expressing neurons
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Approval Evidence
1 source3 linked approval claimsfirst-pass slug near-infrared-light-activatable-nanoparticles
Near‐Infrared‐Light Activatable Nanoparticles for Deep‐Tissue‐Penetrating Wireless Optogenetics
Source:
application summarysupports
NIR-activatable optogenetic tools are described as enabling low-invasive remote-control activation and inhibition of cellular signaling pathways.
These NIR-activatable optogenetic tools enable low-invasive "remote control" activation and inhibition of cellular signaling pathways.
Source:
limitation summarysupports
Conventional optogenetic tools generally rely on visible light with shallow tissue penetration and often require invasive fiber-optic probes for delivery into organs and animal tissues.
current optogenetic tools generally rely on visible light (e.g., blue or yellow) with shallow tissue penetration ability that does require invasive fiber-optic probes to deliver visible light into organs and animal tissues
Source:
safety advantage summarysupports
Wireless optogenetic tools responsive to deep-tissue-penetrating near-infrared light are described as causing much-reduced damage to living organisms compared with invasive visible-light delivery approaches.
the emerging wireless optogenetic tools that can respond to deep-tissue-penetrating near-infrared (NIR) light have attracted increasing attention due to their much-reduced damage to living organisms
Source:
Comparisons
Source-backed strengths
The main reported strength is deep-tissue-penetrating wireless optogenetic actuation using near-infrared light. The source further states that this platform can support both activation and inhibition of cellular signaling pathways with low-invasive remote control.
Ranked Citations
- 1.