Source 1review2024Journal of Biological Chemistry
Toolkit/Opto-CRAC2
Opto-CRAC2
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
The supplied web research summary states that the anchor review explicitly lists Opto-CRAC2 designs using CRY2/CIBN and iLID/SspB and ties them to a mechanistic STIM1 engineering paper.
Usefulness & Problems
No literature-backed usefulness or problem-fit explainer has been materialized for this record yet.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Techniques
Computational DesignTarget processes
signalingInput: Light
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
The review scaffold groups STIM1 optogenetic tools into at least CRY2-based oligomerization designs and LOV2-based unfolding or caging designs for optical control of calcium signaling.
The review scaffold explicitly names OptoSTIM1, monSTIM1, eOS1, Opto-CRAC1, Opto-CRAC2, BACCS, and LOVS1K as STIM1-related optogenetic calcium-control tools or variants within the review scope.
Approval Evidence
1 source2 linked approval claimsfirst-pass slug opto-crac2
The supplied web research summary states that the anchor review explicitly lists Opto-CRAC2 designs using CRY2/CIBN and iLID/SspB and ties them to a mechanistic STIM1 engineering paper.
Source:
design mechanism summarysupports
The review scaffold groups STIM1 optogenetic tools into at least CRY2-based oligomerization designs and LOV2-based unfolding or caging designs for optical control of calcium signaling.
Source:
tool family membershipsupports
The review scaffold explicitly names OptoSTIM1, monSTIM1, eOS1, Opto-CRAC1, Opto-CRAC2, BACCS, and LOVS1K as STIM1-related optogenetic calcium-control tools or variants within the review scope.
Source:
Comparisons
No literature-backed comparison notes have been materialized for this record yet.
Ranked Citations
- 1.