Source 1review2022Frontiers in Bioengineering and Biotechnology
Toolkit/OptoGels
OptoGels
Also known as: optogels
Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
OptoGels are hydrogels whose material properties are programmed by light through incorporation of naturally occurring photoswitchable proteins. They are described as extracellular optogenetic materials that enable dynamic optical control of hydrogel behavior.
Usefulness & Problems
Why this is useful
OptoGels are useful because light-sensitive proteins in extracellular systems can provide precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility. The cited review describes these materials as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell-eluting materials.
Source:
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
Problem solved
OptoGels address the need for dynamically tunable extracellular materials whose properties can be modulated with high spatial and temporal precision. The available evidence indicates that they help solve the problem of controlling hydrogel properties in biological contexts using light rather than static material design alone.
Source:
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Component: A low-level protein part used inside a larger architecture that realizes a mechanism.
Mechanisms
photoswitchingTechniques
Computational DesignTarget processes
recombinationInput: Light
Implementation Constraints
The available evidence indicates that OptoGels are hydrogels endowed with light responsiveness by incorporating naturally occurring photoswitchable proteins. No specific construct architectures, cofactors, host expression systems, crosslinking chemistries, or illumination parameters are provided in the supplied evidence.
The supplied evidence is limited to a review-level description and does not provide specific optoproteins, wavelengths, response kinetics, mechanical performance, or quantitative benchmarks. Independent experimental validation, application-specific performance, and constraints on delivery or fabrication are not established by the provided sources.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Ranked Claims
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Approval Evidence
1 source5 linked approval claimsfirst-pass slug optogels
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
Source:
advantage summarysupports
Light-sensitive proteins used in extracellular systems offer precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility as advantages for dynamic control of material properties.
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Source:
application scopesupports
The review describes OptoGels as promising for mechanobiology, 3D cell and organoid engineering, and programmable cell eluting materials.
OptoGels show great promise in applications ranging from mechanobiology, to 3D cell and organoid engineering, and programmable cell eluting materials.
Source:
definitionsupports
OptoGels are hydrogels with light-programmable properties endowed by photoswitchable proteins.
OptoGels: hydrogels with light-programmable properties endowed by photoswitchable proteins ("optoproteins") found in nature.
Source:
design space summarysupports
Available conjugation chemistries create a combinatorially large OptoGel design space determined by combinations of optoproteins and polymer networks, yielding tunable material properties.
Available conjugation chemistries endow OptoGels with a combinatorially large design space determined by the set of optoproteins and polymer networks. These combinations result in a variety of tunable material properties.
Source:
field gapsupports
Relatively little of the OptoGel design space has been explored.
Despite their potential, relatively little of the OptoGel design space has been explored.
Source:
Comparisons
Source-backed strengths
Reported advantages of the underlying extracellular optogenetic approach include precise spatiotemporal control, reversibility, substrate selectivity, biodegradability, and biocompatibility. The concept is positioned as broadly relevant to mechanobiology and engineered 3D culture systems.
Source:
light-sensitive proteins have several distinct advantages, including precise spatiotemporal control, reversibility, substrate selectivity, as well as biodegradability and biocompatibility
Ranked Citations
- 1.