Source 1primary paper2017Scientia Sinica Vitae
Toolkit/optogenetic networks
optogenetic networks
Also known as: light-controlled genetic devices, optogenetic gene circuits, optogenetic modules, optogenetic systems, synthetic optogenetic networks
Taxonomy: Mechanism Branch / Architecture. Workflows sit above the mechanism and technique branches rather than replacing them.
Summary
Optogenetic networks are multi-component light-controlled genetic devices built from genetically encoded photosensitive proteins to regulate cellular behaviors and biological processes. They are developed to provide user-defined, minimally invasive, and spatiotemporally precise control for biomedical applications, including human disease therapy.
Usefulness & Problems
Why this is useful
These systems are useful because light stimulation can regulate cellular behavior with spatiotemporal precision and minimal invasiveness. The cited literature positions them as platforms for gene- and cell-based therapies and for controlling biological processes relevant to metabolic disorders, cancer, and immune diseases.
Source:
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Source:
Various optogenetic systems have been engineered to control biological processes at all levels using light and applied for numerous diseases, such as metabolic disorders, cancer, and immune diseases.
Source:
optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative technology platform to revolutionize manipulation of cellular behavior through light stimulation. It has enabled user defined control of various cellular behaviors with spatiotemporal precision and minimal invasiveness
Source:
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Problem solved
Optogenetic networks address the need for externally controllable genetic systems that can modulate cellular and biological processes with high spatial and temporal resolution. They are specifically framed as tools for biomedical intervention where precise control of therapeutic cellular behavior is required.
Source:
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Source:
Various optogenetic systems have been engineered to control biological processes at all levels using light and applied for numerous diseases, such as metabolic disorders, cancer, and immune diseases.
Taxonomy & Function
Primary hierarchy
Mechanism Branch
Architecture: A composed arrangement of multiple parts that instantiates one or more mechanisms.
Mechanisms
light-dependent control of genetically encoded photosensitive proteinsspatiotemporal regulation of cellular behavior by light stimulationTarget processes
No target processes tagged yet.
Input: Light
Implementation Constraints
Implementation is described at a general level as the design and construction of light-controlled genetic devices using genetically encoded photosensitive proteins. The supplied evidence does not specify particular photoreceptors, cofactors, host organisms, delivery methods, or construct architectures.
The supplied evidence indicates that further development of optogenetic modules is needed to more precisely control gene expression magnitude for clinical medical practice. No specific quantitative performance metrics, wavelength-specific operating ranges, or comparative benchmarking data are provided in the supplied evidence.
Validation
Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication
Supporting Sources
Source 2primary paper2017Quantitative Biology
Ranked Claims
Optogenetic networks are designed for biomedical applications, including human disease therapy.
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Optogenetic networks are designed for biomedical applications, including human disease therapy.
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Optogenetic networks are designed for biomedical applications, including human disease therapy.
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Optogenetic networks are designed for biomedical applications, including human disease therapy.
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Optogenetic networks are designed for biomedical applications, including human disease therapy.
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Optogenetic networks are designed for biomedical applications, including human disease therapy.
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Various optogenetic systems have been engineered to control biological processes at all levels and have been applied to diseases including metabolic disorders, cancer, and immune diseases.
Various optogenetic systems have been engineered to control biological processes at all levels using light and applied for numerous diseases, such as metabolic disorders, cancer, and immune diseases.
Optogenetics based on genetically encoded photosensitive proteins enables user-defined control of various cellular behaviors through light stimulation with spatiotemporal precision and minimal invasiveness.
optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative technology platform to revolutionize manipulation of cellular behavior through light stimulation. It has enabled user defined control of various cellular behaviors with spatiotemporal precision and minimal invasiveness
Optogenetics enables spatiotemporal control of cellular behaviors through light stimulation for gene- and cell-based therapies.
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Optogenetics enables spatiotemporal control of cellular behaviors through light stimulation for gene- and cell-based therapies.
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Optogenetics enables spatiotemporal control of cellular behaviors through light stimulation for gene- and cell-based therapies.
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Optogenetics enables spatiotemporal control of cellular behaviors through light stimulation for gene- and cell-based therapies.
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Optogenetics enables spatiotemporal control of cellular behaviors through light stimulation for gene- and cell-based therapies.
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Optogenetics enables spatiotemporal control of cellular behaviors through light stimulation for gene- and cell-based therapies.
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Continued development of optogenetic modules is needed to more precisely control gene expression magnitude for clinical medical practice.
Continued development of optogenetic modules will be necessary to precisely control of gene expression magnitude towards clinical medical practice in the context of real-world problems.
Approval Evidence
2 sources5 linked approval claimsfirst-pass slug optogenetic-networks
This article reviews current advances in optogenetic networks designed for the treatment of human diseases. ... Various optogenetic systems have been engineered to control biological processes at all levels using light ...
Source:
we describe the most recent advances in optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Source:
applicationsupports
Optogenetic networks are designed for biomedical applications, including human disease therapy.
optogenetic networks designed for biomedical applications, including how light-controlled genetic devices can be designed and constructed for human disease therapy
Source:
application scopesupports
Various optogenetic systems have been engineered to control biological processes at all levels and have been applied to diseases including metabolic disorders, cancer, and immune diseases.
Various optogenetic systems have been engineered to control biological processes at all levels using light and applied for numerous diseases, such as metabolic disorders, cancer, and immune diseases.
Source:
capabilitysupports
Optogenetics based on genetically encoded photosensitive proteins enables user-defined control of various cellular behaviors through light stimulation with spatiotemporal precision and minimal invasiveness.
optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative technology platform to revolutionize manipulation of cellular behavior through light stimulation. It has enabled user defined control of various cellular behaviors with spatiotemporal precision and minimal invasiveness
Source:
capabilitysupports
Optogenetics enables spatiotemporal control of cellular behaviors through light stimulation for gene- and cell-based therapies.
Optogenetics ... enables spatiotemporal control of cellular behaviors used for gene- and cell-based therapies through light stimulation.
Source:
development needsupports
Continued development of optogenetic modules is needed to more precisely control gene expression magnitude for clinical medical practice.
Continued development of optogenetic modules will be necessary to precisely control of gene expression magnitude towards clinical medical practice in the context of real-world problems.
Source:
Comparisons
Source-backed strengths
Reported strengths include user-defined control, spatiotemporal precision, and minimal invasiveness through the use of genetically encoded photosensitive proteins and light stimulation. The literature also states that optogenetic systems have been engineered to control biological processes at multiple levels and have been applied across several disease areas.
Ranked Citations
- 1.