Toolkit/optogenetic RGS2

optogenetic RGS2

Protein Domain·Research·Since 2018

Also known as: opto-RGS2

Taxonomy: Mechanism Branch / Component. Workflows sit above the mechanism and technique branches rather than replacing them.

Summary

Optogenetic RGS2 (opto-RGS2) is an engineered light-responsive RGS2-based protein tool created to study calcium encoding in Gq-protein signaling. It uses light-induced heterodimerization to recruit an RGS2 domain to the membrane, where it interacts with its cognate G protein and modulates calcium oscillatory behavior.

Usefulness & Problems

Why this is useful

opto-RGS2 is useful for experimentally controlling Gq-linked calcium oscillation dynamics with light in an engineered cell-line context. In the cited study, it enabled optical re-creation of calcium oscillation patterns that independently varied a single waveform component, supporting analysis of calcium encoding.

Source:

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Source:

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

Problem solved

This tool addresses the problem of perturbing Gq-protein signaling with temporal precision to test how specific features of calcium oscillations are generated and regulated. The reported application was to study how RGS2 functions within the signaling circuit controlling periodic and stochastic calcium responses.

Source:

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

Problem links

Need conditional control of signaling activity

Derived

Optogenetic RGS2 (opto-RGS2) is an engineered light-responsive RGS2-based protein tool developed to study calcium encoding in Gq-protein signaling. It uses light-induced heterodimerization to recruit an RGS2 domain to the membrane, where it interacts with its cognate G protein and modulates calcium oscillatory behavior.

Need conditional recombination or state switching

Derived

Optogenetic RGS2 (opto-RGS2) is an engineered light-responsive RGS2-based protein tool developed to study calcium encoding in Gq-protein signaling. It uses light-induced heterodimerization to recruit an RGS2 domain to the membrane, where it interacts with its cognate G protein and modulates calcium oscillatory behavior.

Need precise spatiotemporal control with light input

Derived

Optogenetic RGS2 (opto-RGS2) is an engineered light-responsive RGS2-based protein tool developed to study calcium encoding in Gq-protein signaling. It uses light-induced heterodimerization to recruit an RGS2 domain to the membrane, where it interacts with its cognate G protein and modulates calcium oscillatory behavior.

Taxonomy & Function

Primary hierarchy

Mechanism Branch

Component: A low-level protein part used inside a larger architecture that realizes a mechanism.

Techniques

No technique tags yet.

Target processes

recombinationsignaling

Input: Light

Implementation Constraints

cofactor dependency: cofactor requirement unknownencoding mode: genetically encodedimplementation constraint: context specific validationimplementation constraint: multi component delivery burdenimplementation constraint: spectral hardware requirementoperating role: regulatorswitch architecture: multi componentswitch architecture: recruitment

The reported implementation combined an engineered opto-RGS2 cell line with a light-induced heterodimerization system that recruits the RGS2 domain to the membrane. The study also used mathematical modeling and custom hardware, but the supplied evidence does not specify cofactors, expression system details, or the exact heterodimerization pair.

The available evidence is limited to a single cited study in an engineered cell line and does not report broader validation across cell types, organisms, or in vivo settings. Practical performance details such as light wavelength, kinetics, dynamic range, and construct architecture are not provided in the supplied evidence.

Validation

Cell-freeBacteriaMammalianMouseHumanTherapeuticIndep. Replication

Supporting Sources

Ranked Claims

Claim 1experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 2experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 3experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 4experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 5experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 6experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 7experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 8experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 9experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 10experimental capabilitysupports2018Source 1needs review

Using a mathematical model, an optogenetically engineered cell line, and custom hardware, the authors optically re-created patterns of calcium oscillations that independently varied a single waveform component.

Using a mathematical model, an optogenetically-engineered cell line, and custom hardware, we optically re-created patterns of calcium oscillations that independently varied a single waveform component.
Claim 11functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 12functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 13functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 14functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 15functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 16functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 17functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 18functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 19functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 20functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 21functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 22functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 23functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 24functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 25functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 26functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 27functional effectsupports2018Source 1needs review

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.
Claim 28mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 29mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 30mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 31mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 32mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 33mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 34mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 35mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 36mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 37mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 38mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 39mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 40mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 41mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 42mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 43mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 44mechanismsupports2018Source 1needs review

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.
Claim 45tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 46tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 47tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 48tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 49tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 50tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 51tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 52tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 53tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 54tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 55tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 56tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 57tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 58tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 59tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 60tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.
Claim 61tool developmentsupports2018Source 1needs review

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

Approval Evidence

1 source3 linked approval claimsfirst-pass slug optogenetic-rgs2
First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

Source:

functional effectsupports

Using the engineered opto-RGS2 cell line, RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Using our engineered opto-RGS2 cell line, we revealed that RGS2 reduced periodicity and stochasticity of G-protein coupled calcium oscillations and acted as a feedback regulator in this signaling circuit.

Source:

mechanismsupports

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

A light-induced hetero-dimerization system was engineered to recruit the RGS2 domain to the membrane where it interacted with its cognate G protein.

Source:

tool developmentsupports

The authors developed optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

First, we created optogenetic RGS2 (opto-RGS2) for studying calcium encoding.

Source:

Comparisons

Source-backed strengths

The tool was specifically engineered for light-dependent membrane recruitment of an RGS2 domain to its site of action on cognate G protein signaling. In the reported engineered cell line, opto-RGS2 reduced periodicity and stochasticity of G-protein-coupled calcium oscillations and functioned as a feedback regulator, demonstrating functional control over oscillatory signaling.

Compared with ITSN1 GEF domain

optogenetic RGS2 and ITSN1 GEF domain address a similar problem space because they share recombination, signaling.

Shared frame: same top-level item type; shared target processes: recombination, signaling; shared mechanisms: heterodimerization; same primary input modality: light

Compared with p63RhoGEF GEF domain

optogenetic RGS2 and p63RhoGEF GEF domain address a similar problem space because they share recombination, signaling.

Shared frame: same top-level item type; shared target processes: recombination, signaling; shared mechanisms: heterodimerization; same primary input modality: light

Compared with TIAM1 GEF domain

optogenetic RGS2 and TIAM1 GEF domain address a similar problem space because they share recombination, signaling.

Shared frame: same top-level item type; shared target processes: recombination, signaling; shared mechanisms: heterodimerization; same primary input modality: light

Ranked Citations

  1. 1.
    StructuralSource 1Scholarly Commons (University of Pennsylvania)2018Claim 9Claim 10Claim 9

    Extracted from this source document.